{"id":"W2152823264","doi":"10.1093/toxsci/67.1.121","title":"Evaluation of the Aromatase Inhibitor Fadrozole in a Short-Term Reproduction Assay with the Fathead Minnow (Pimephales promelas)","year":2002,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Reproductive biology and impacts on aquatic species","field":"Biochemistry, Genetics and Molecular Biology","cited_by":286,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"McMaster University; U.S. Environmental Protection Agency","keywords":"Biology; Aromatase; Vitellogenin; Minnow; Aromatase inhibitor; Internal medicine; Endocrinology; Pimephales promelas; Endocrine disruptor; Testosterone (patch); Endocrine system; Hormone; Genetics; Fishery","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001145486,0.0002721639,0.000197442,0.000141605,0.0001289604,0.0001334285,0.0001835039,0.0001920143,0.0005986365],"category_scores_gemma":[0.0001732888,0.0001087394,0.0002233346,0.0001049811,0.0001068499,0.0001378521,0.00009292564,0.0002372196,0.0001328941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001780143,"about_ca_system_score_gemma":0.0001905354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001236512,"about_ca_topic_score_gemma":0.003644908,"domain_scores_codex":[0.9999105,0.00001593233,0.000009951702,0.00002349923,0.00002783746,0.00001226969],"domain_scores_gemma":[0.9998993,0.00001636415,0.00003618211,0.000005980446,0.00002407473,0.00001808701],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005616645,0.000113318,0.0009915439,0.00007374043,0.00002370345,0.00003915152,0.000022414,0.000103266,0.992358,0.00001842414,0.0000594489,0.005635265],"study_design_scores_gemma":[0.00003755315,0.007500245,0.01580763,0.000008078829,0.0001142099,0.0001739346,0.00005512438,0.0004926337,0.9734123,0.00001328813,0.002377016,0.000007953919],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994218,0.002623778,0.001504216,0.00009040981,0.0000437265,0.00005558662,0.0004527583,0.00004603927,0.0009655101],"genre_scores_gemma":[0.9894589,0.002893642,0.003489095,0.00007099236,0.00002386944,0.00008838816,0.0007109782,0.00001006431,0.003254028],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001236512,"threshold_uncertainty_score":0.002458632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07740181459957451,"score_gpt":0.3101203953675489,"score_spread":0.2327185807679744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}