{"id":"W2152823264","doi":"10.1093/toxsci/67.1.121","title":"Evaluation of the Aromatase Inhibitor Fadrozole in a Short-Term Reproduction Assay with the Fathead Minnow (Pimephales promelas)","year":2002,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Reproductive biology and impacts on aquatic species","field":"Biochemistry, Genetics and Molecular Biology","cited_by":286,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"McMaster University; U.S. Environmental Protection Agency","keywords":"Biology; Aromatase; Vitellogenin; Minnow; Aromatase inhibitor; Internal medicine; Endocrinology; Pimephales promelas; Endocrine disruptor; Testosterone (patch); Endocrine system; Hormone; Genetics; Fishery","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003227988,0.00009629719,0.0001056616,0.00002553435,0.0001666011,0.00001981713,0.0003079771,0.00008761235,0.0001049974],"category_scores_gemma":[0.001233043,0.00003973368,0.00003735465,0.000324832,0.001209846,0.00001242295,0.00007612816,0.00008354754,0.000004240266],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002284082,"about_ca_system_score_gemma":0.00005272334,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000496501,"about_ca_topic_score_gemma":0.00009354347,"domain_scores_codex":[0.9982971,0.000543714,0.0001653938,0.0004158349,0.0004010838,0.0001769055],"domain_scores_gemma":[0.99942,0.00004074946,0.00007471698,0.0003389812,0.0001030529,0.00002250634],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004438749,0.0003287413,0.04173666,0.000003579569,0.00002025316,5.673505e-7,0.0002235593,0.0002133675,0.9421218,0.0001301709,0.001450961,0.01372596],"study_design_scores_gemma":[0.0003026979,0.001268995,0.4248832,0.00001731107,0.00003506496,0.00002980418,0.000470558,0.0004065254,0.5705423,0.0002946879,0.001610457,0.0001384364],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940031,0.000794019,0.00001285137,0.002808482,0.00009241865,0.0004850193,0.000003950187,0.000004881663,0.001795264],"genre_scores_gemma":[0.9994687,0.00003049486,0.00006948219,0.00007639086,0.0001169412,0.00005161518,0.000002760229,0.000002349361,0.0001812435],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3831465,"threshold_uncertainty_score":0.4457729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07740181459957451,"score_gpt":0.3101203953675489,"score_spread":0.2327185807679744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}