{"id":"W2152830821","doi":"10.2217/hiv.09.40","title":"The K65R Mutation in HIV-1 Reverse Transcriptase: Genetic Barriers, Resistance Profile and Clinical Implications","year":2009,"lang":"en","type":"article","venue":"HIV Therapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Resistance mutation; Stavudine; Lamivudine; Virology; Nevirapine; Biology; Zidovudine; Emtricitabine; Didanosine; Abacavir; Reverse transcriptase; Drug resistance; Genetics; Viral load; Human immunodeficiency virus (HIV); Virus; RNA; Viral disease; Antiretroviral therapy; Hepatitis B virus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002294818,0.0001054675,0.0001557699,0.00004212045,0.0001458962,0.0000193609,0.00005617638,0.00005400191,0.00005474608],"category_scores_gemma":[0.00003217365,0.00007109319,0.00005025471,0.0001534827,0.00007178901,0.00004068624,0.000002653992,0.0001086242,0.00003386935],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004464878,"about_ca_system_score_gemma":0.0001003086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001601545,"about_ca_topic_score_gemma":0.0000269347,"domain_scores_codex":[0.9991326,0.0000809401,0.0002965808,0.0002172549,0.0001069769,0.0001656519],"domain_scores_gemma":[0.9994988,0.00007674853,0.00004930929,0.0002350747,0.00003449646,0.0001055327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002538155,0.0008098307,0.431681,0.00003077997,0.0002941807,0.000185044,0.005203013,0.000002105088,0.0030835,0.004805105,0.2783999,0.2729674],"study_design_scores_gemma":[0.003859538,0.0001234935,0.7696778,0.00004838248,0.00003469906,0.0000144879,0.00017999,0.00003869886,0.0002795813,0.001266363,0.2243663,0.0001107199],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7938147,0.008562198,0.0004628896,0.1917758,0.0001104255,0.001988156,0.00005065893,0.00009156783,0.003143656],"genre_scores_gemma":[0.9506981,0.01001652,0.008258742,0.002129778,0.0001063316,0.0001510331,0.0001304284,0.00002173176,0.02848733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3379968,"threshold_uncertainty_score":0.2899096,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01831863474859166,"score_gpt":0.3086983567991576,"score_spread":0.2903797220505659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}