{"id":"W2152830821","doi":"10.2217/hiv.09.40","title":"The K65R Mutation in HIV-1 Reverse Transcriptase: Genetic Barriers, Resistance Profile and Clinical Implications","year":2009,"lang":"en","type":"article","venue":"HIV Therapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Resistance mutation; Stavudine; Lamivudine; Virology; Nevirapine; Biology; Zidovudine; Emtricitabine; Didanosine; Abacavir; Reverse transcriptase; Drug resistance; Genetics; Viral load; Human immunodeficiency virus (HIV); Virus; RNA; Viral disease; Antiretroviral therapy; Hepatitis B virus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009220963,0.0002173541,0.0003591324,0.0003568274,0.0001523941,0.000807771,0.0002915104,0.000561212,0.001358803],"category_scores_gemma":[0.001328368,0.00009888674,0.0001391321,0.0004276023,0.0004519896,0.0007762316,0.0002447298,0.0005856929,0.0005128153],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003607926,"about_ca_system_score_gemma":0.000433561,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006901553,"about_ca_topic_score_gemma":0.0006262363,"domain_scores_codex":[0.9996629,0.0001176462,0.00003247919,0.00004909303,0.00009195931,0.00004582589],"domain_scores_gemma":[0.999393,0.0002458875,0.0001799578,0.00001631831,0.00008154776,0.0000832605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.004263782,0.0008676135,0.2349896,0.002575347,0.0001366256,0.008907077,0.0008995404,0.001526267,0.05494962,0.00952026,0.006702496,0.6746619],"study_design_scores_gemma":[0.0002814902,0.008889953,0.7467664,0.001735509,0.0004390069,0.08547816,0.003313406,0.004754666,0.01605991,0.01960214,0.1124838,0.0001956488],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6838948,0.2903896,0.001930043,0.0116217,0.0001808269,0.00004244633,0.0002195283,0.00005253051,0.01166853],"genre_scores_gemma":[0.9678769,0.02901262,0.0006449466,0.0008342755,0.0003485298,0.00001660928,0.0000986493,0.00001040566,0.001157039],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001358803,"threshold_uncertainty_score":0.004876554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01831863474859166,"score_gpt":0.3086983567991576,"score_spread":0.2903797220505659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}