{"id":"W2152856891","doi":"10.3389/fonc.2011.00020","title":"Integration of Principles of Systems Biology and Radiation Biology: Toward Development of in silico Models to Optimize IUdR-Mediated Radiosensitization of DNA Mismatch Repair Deficient (Damage Tolerant) Human Cancers","year":2011,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University; National Institutes of Health","keywords":"In silico; Radiation tolerance; Radiobiology; DNA repair; Cancer research; DNA damage; Radiation oncology; Computational biology; Biology; DNA Damage Repair; Systems biology; Radiation therapy; DNA; Medical physics; Medicine; Genetics; Internal medicine; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008502866,0.0008586964,0.001078057,0.0004283877,0.0003672897,0.001091326,0.001042606,0.001207488,0.0009350271],"category_scores_gemma":[0.002016992,0.0005949163,0.00107395,0.0003388458,0.0008778183,0.0009125932,0.0007240425,0.0009815216,0.0002209784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001268179,"about_ca_system_score_gemma":0.001437122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004572825,"about_ca_topic_score_gemma":0.00313878,"domain_scores_codex":[0.9997053,0.0001491132,0.00001355488,0.00003866245,0.00007092811,0.00002248102],"domain_scores_gemma":[0.9991384,0.0006652446,0.0000669894,0.00004215953,0.00005684687,0.00003046682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.000006299917,0.00001365407,0.0002114398,0.00003082658,0.0000136438,0.00001276075,0.00001542512,0.9926974,0.0006521661,0.005306537,0.00006372571,0.0009761728],"study_design_scores_gemma":[0.000006280697,0.00001227856,0.00007037599,0.000005498093,0.000006195949,0.000005768682,0.000005632214,0.9949788,0.0003563475,0.004082777,0.0004659206,0.000003940072],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.138595,0.001991237,0.8429896,0.002159721,0.0001519794,0.0001945899,0.0004553986,0.0005857961,0.0128767],"genre_scores_gemma":[0.8385989,0.00403708,0.1516152,0.0004009642,0.000111399,0.0007204313,0.0004403682,0.0002746483,0.003801143],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.004572825,"threshold_uncertainty_score":0.009201348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03501217558966982,"score_gpt":0.2761577197554222,"score_spread":0.2411455441657524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}