{"id":"W2152859536","doi":"10.1093/hmg/ddr504","title":"The accumulation and not the specific activity of telomerase ribonucleoprotein determines telomere maintenance deficiency in X-linked dyskeratosis congenita","year":2011,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health; Michael Smith Health Research BC","keywords":"Dyskeratosis congenita; Telomere; Telomerase; Biology; Telomerase reverse transcriptase; Molecular biology; Cancer research; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003777326,0.0002586067,0.0003281483,0.0001256759,0.0002330002,0.00004152125,0.0002754416,0.0001199709,0.00002046624],"category_scores_gemma":[0.0001050955,0.0001711414,0.00009771361,0.0003511116,0.0005793002,0.00005413373,0.0001113732,0.0002723462,0.000004603773],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003800847,"about_ca_system_score_gemma":0.00006018607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000126488,"about_ca_topic_score_gemma":0.0002680066,"domain_scores_codex":[0.9982167,0.0001517344,0.000471135,0.000398445,0.0003651392,0.000396874],"domain_scores_gemma":[0.9986255,0.0001015018,0.0002105216,0.0007772003,0.0001792482,0.0001059912],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003204438,0.0002150998,0.04954703,0.0001047546,0.00004155351,0.0001121133,0.001905093,0.00001402397,0.9066,0.001482477,0.00004042111,0.03961701],"study_design_scores_gemma":[0.0009583085,0.0002421552,0.7775829,0.0000779897,0.00005833833,0.00004022119,0.0002494614,0.0005306638,0.2191384,0.0005109045,0.0003916494,0.0002190475],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958072,0.002451875,0.0002390052,0.0001811667,0.00007147742,0.0008322138,0.00000746843,0.0000358642,0.0003737427],"genre_scores_gemma":[0.9981704,0.0007373495,0.0007664087,0.0001449791,0.00003700705,0.00003700113,0.000003485965,0.00004797638,0.00005539137],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7280359,"threshold_uncertainty_score":0.6978944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06712084395061288,"score_gpt":0.290646160335136,"score_spread":0.2235253163845231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}