{"id":"W2152872028","doi":"10.1093/glycob/10.8.815","title":"The heterodimeric structure of glucosidase II is required for its activity, solubility, and localization in vivo","year":2000,"lang":"en","type":"article","venue":"Glycobiology","topic":"Transgenic Plants and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":123,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute","funders":"Natural Sciences and Engineering Research Council of Canada; Medical Research Council Canada; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Calnexin; Protein subunit; Biochemistry; Glycoprotein; G alpha subunit; Complementary DNA; Castanospermine; Endoplasmic reticulum; Glycosylation; Enzyme; Molecular biology; Biology; Chemistry; Calreticulin; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000210703,0.0004333561,0.000265481,0.000150937,0.0001482555,0.0006547977,0.0001813164,0.0002236308,0.001179424],"category_scores_gemma":[0.0001993564,0.0002242504,0.0001926288,0.0001808254,0.0001673118,0.0002313403,0.0002717022,0.0004565069,0.001167699],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002913865,"about_ca_system_score_gemma":0.000223928,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004342717,"about_ca_topic_score_gemma":0.0005128058,"domain_scores_codex":[0.999742,0.00003719523,0.0000316087,0.00007444599,0.00007076667,0.00004400863],"domain_scores_gemma":[0.9997374,0.00003359967,0.00008010577,0.00003707232,0.00003260678,0.00007916156],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004036068,0.00001417875,0.0002320173,0.00001182191,0.000002777693,0.0000249336,0.000007706572,0.00001619727,0.9988833,0.00006626164,0.0000507788,0.0006496287],"study_design_scores_gemma":[0.00002472998,0.0001423494,0.01676785,0.00001727646,0.00002235097,0.0006511457,0.00005694797,0.00147387,0.9711468,0.0001312997,0.009556293,0.000009012385],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896657,0.002319857,0.005298274,0.0001244218,0.00005304699,0.00002500534,0.0006595559,0.0001497933,0.001704174],"genre_scores_gemma":[0.9882903,0.001161823,0.00300215,0.00008095735,0.00003832823,0.00004203683,0.00298381,0.0001024547,0.004298235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001179424,"threshold_uncertainty_score":0.003945589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009543204344674046,"score_gpt":0.254064392658713,"score_spread":0.244521188314039,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}