{"id":"W2152926085","doi":"10.1161/01.hyp.0000083511.91817.b1","title":"Peroxisome Proliferator-Activated Receptor-α and Receptor-γ Activators Prevent Cardiac Fibrosis in Mineralocorticoid-Dependent Hypertension","year":2003,"lang":"en","type":"article","venue":"Hypertension","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":145,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute; Montreal Clinical Research Institute","funders":"Hypertension Canada; Fondation pour la Recherche Médicale","keywords":"Internal medicine; Endocrinology; Fenofibrate; Rosiglitazone; Mineralocorticoid receptor; Medicine; Ventricle; Peroxisome proliferator-activated receptor; Cardiac fibrosis; Aldosterone; Receptor; Fibrosis; Blood pressure; Atrial natriuretic peptide; Peroxisome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001959634,0.0004928896,0.0006586196,0.0003672974,0.0002900452,0.0002514046,0.0002953038,0.0003201682,0.001228989],"category_scores_gemma":[0.0001490808,0.0002869323,0.0004155459,0.000179792,0.0004000371,0.0003356585,0.0001852535,0.001144169,0.0002562971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001833393,"about_ca_system_score_gemma":0.0005197535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001298558,"about_ca_topic_score_gemma":0.003695751,"domain_scores_codex":[0.9998727,0.00002081489,0.00001563487,0.0000196004,0.00002560207,0.00004568914],"domain_scores_gemma":[0.9997597,0.0000210252,0.00004011898,0.00002940785,0.0000163333,0.0001333311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003343604,0.0005251761,0.0005021185,0.0000603797,0.0000202742,0.00007346432,0.00002591236,0.00004791268,0.9916177,0.00005040459,0.0000618922,0.003671131],"study_design_scores_gemma":[0.001116099,0.01288672,0.02566347,0.00002300237,0.0001957533,0.0004233868,0.000161098,0.0006607116,0.9554643,0.0001358418,0.003245415,0.00002417654],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974982,0.0008681866,0.0007758139,0.0001337781,0.00006427513,0.00003498593,0.000148199,0.00004991332,0.0004264904],"genre_scores_gemma":[0.98913,0.002667262,0.002394076,0.0001495651,0.00007581485,0.0001208013,0.0006139618,0.00002852075,0.00482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001298558,"threshold_uncertainty_score":0.00411135,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01199983128108729,"score_gpt":0.2166462391110646,"score_spread":0.2046464078299774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}