{"id":"W2152964734","doi":"10.1124/dmd.31.7.815","title":"THE CONDUCT OF IN VITRO AND IN VIVO DRUG-DRUG INTERACTION STUDIES: A PHARMACEUTICAL RESEARCH AND MANUFACTURERS OF AMERICA (PhRMA) PERSPECTIVE","year":2003,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":784,"is_retracted":false,"has_abstract":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Pharmaceutical industry; Drug; Pharmacology; Business; Drug development; In vivo; Medicine; Biology; Biotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.09618574,0.001120735,0.003172859,0.002661797,0.00145808,0.007480149,0.003072371,0.007155532,0.004854652],"category_scores_gemma":[0.07019285,0.00109298,0.001309109,0.002243904,0.005571362,0.006102028,0.001916768,0.007449649,0.001481308],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0023927,"about_ca_system_score_gemma":0.009488428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003063063,"about_ca_topic_score_gemma":0.009211333,"domain_scores_codex":[0.9342147,0.04883922,0.00386346,0.002404883,0.009886582,0.0007911943],"domain_scores_gemma":[0.7917438,0.1446776,0.01375797,0.008136493,0.03681242,0.004871696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001922586,0.002589973,0.02758752,0.003042498,0.0007010406,0.0007758296,0.0009953254,0.001957772,0.06443174,0.04547347,0.04471627,0.805806],"study_design_scores_gemma":[0.0007350656,0.01940746,0.06261149,0.002474469,0.001674753,0.006232475,0.005129542,0.006449374,0.09650543,0.07130916,0.7271109,0.0003598908],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"commentary","genre_scores_codex":[0.03745858,0.3159289,0.262241,0.2890231,0.009348489,0.00171702,0.001598273,0.0008877018,0.081797],"genre_scores_gemma":[0.2734265,0.1511512,0.4382686,0.1004582,0.01751848,0.001442114,0.001045999,0.0003954907,0.01629339],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.09618574,"threshold_uncertainty_score":0.5086849,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1330846748823761,"score_gpt":0.4867489728515031,"score_spread":0.353664297969127,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}