{"id":"W2152989668","doi":"10.1128/jvi.75.2.589-594.2001","title":"Human Immunodeficiency Virus Type 1 Protease Cleavage Site Mutations Associated with Protease Inhibitor Cross-Resistance Selected by Indinavir, Ritonavir, and/or Saquinavir","year":2001,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":131,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital","funders":"","keywords":"Indinavir; Saquinavir; Ritonavir; Protease; Biology; Virology; Cleavage (geology); Reverse transcriptase; Lentivirus; Protease inhibitor (pharmacology); Molecular biology; Virus; HIV-1 protease; Sida; Viral disease; Biochemistry; Enzyme; Viral load; Polymerase chain reaction; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003770418,0.000275768,0.0005537735,0.0002456104,0.0003295539,0.00004998411,0.0001107857,0.000195782,0.0001372096],"category_scores_gemma":[0.0003501538,0.0001914925,0.00006789563,0.0006809205,0.0002763974,0.0002359683,0.00003334916,0.0005451686,0.00002561068],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002390898,"about_ca_system_score_gemma":0.0003801858,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002275153,"about_ca_topic_score_gemma":0.00008637075,"domain_scores_codex":[0.9980788,0.0001702807,0.000665232,0.000274356,0.0003954687,0.000415871],"domain_scores_gemma":[0.9984195,0.00008322102,0.0006225869,0.0001774526,0.0004664446,0.0002307489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01391408,0.005664015,0.5220774,0.0001046757,0.001061656,0.006694433,0.002336099,0.00001154053,0.4385716,0.00003898468,0.008377206,0.001148314],"study_design_scores_gemma":[0.02586825,0.01129965,0.9101183,0.0008466228,0.00110181,0.002863375,0.0002255329,0.00004869694,0.03041281,0.0001759859,0.01624877,0.0007901653],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968371,0.0008740422,0.00003723249,0.001080961,0.00006735826,0.0007525978,0.00003257099,0.00004112628,0.0002770198],"genre_scores_gemma":[0.9867973,0.00008374132,0.0005693443,0.0001827223,0.00007623859,0.00004159683,0.00008645916,0.00003866605,0.01212394],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4081587,"threshold_uncertainty_score":0.7808837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01301657331480484,"score_gpt":0.2938709748038857,"score_spread":0.2808544014890809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}