{"id":"W2152989668","doi":"10.1128/jvi.75.2.589-594.2001","title":"Human Immunodeficiency Virus Type 1 Protease Cleavage Site Mutations Associated with Protease Inhibitor Cross-Resistance Selected by Indinavir, Ritonavir, and/or Saquinavir","year":2001,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":131,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital","funders":"","keywords":"Indinavir; Saquinavir; Ritonavir; Protease; Biology; Virology; Cleavage (geology); Reverse transcriptase; Lentivirus; Protease inhibitor (pharmacology); Molecular biology; Virus; HIV-1 protease; Sida; Viral disease; Biochemistry; Enzyme; Viral load; Polymerase chain reaction; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003220552,0.0003779954,0.0003612574,0.0007586372,0.0004192613,0.0004165624,0.0001944179,0.0004514914,0.001407445],"category_scores_gemma":[0.001492791,0.0003169825,0.0002390683,0.0003315943,0.0003448727,0.0002414735,0.0001815003,0.000389982,0.0001804756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001962958,"about_ca_system_score_gemma":0.00009719787,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007307892,"about_ca_topic_score_gemma":0.0008170957,"domain_scores_codex":[0.9995505,0.0001160501,0.00004831085,0.0001169126,0.00008105095,0.00008715456],"domain_scores_gemma":[0.999084,0.0002282359,0.0003513478,0.00006547167,0.00007370787,0.0001972305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004621133,0.0001181262,0.9847039,0.0000166679,0.0000701785,0.002177186,0.0002354263,0.00004217009,0.007293938,0.00002569405,0.00007314285,0.004781379],"study_design_scores_gemma":[0.00005778587,0.001111795,0.9726056,0.000007174782,0.00007807989,0.02299832,0.0002014822,0.0002934226,0.002305418,0.00002881214,0.0003035926,0.000008481205],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9997633,0.0001053727,0.00002141834,0.000006197688,0.000001189913,0.000002601528,0.00001387326,0.000001270746,0.00008468291],"genre_scores_gemma":[0.9998215,0.00004130049,0.00003831886,0.000009555782,0.000004828486,0.000001546663,0.0000361734,7.875419e-7,0.00004601365],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001407445,"threshold_uncertainty_score":0.00470835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01301657331480484,"score_gpt":0.2938709748038857,"score_spread":0.2808544014890809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}