{"id":"W2153016097","doi":"10.1101/gad.1907510","title":"Pleiotropic role for<i>MYCN</i>in medulloblastoma","year":2010,"lang":"en","type":"article","venue":"Genes & Development","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":174,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Institute of Neurological Disorders and Stroke; National Cancer Institute; National Institutes of Health; Vetenskapsrådet; University of California, San Francisco; Pediatric Brain Tumor Foundation; Samuel Waxman Cancer Research Foundation; Children's Brain Tumor Foundation; Accelerate Brain Cancer Cure; Alexander and Margaret Stewart Trust","keywords":"Medulloblastoma; Biology; Cancer research; Sonic hedgehog; Pathogenesis; Tumor initiation; Penetrance; Hedgehog signaling pathway; Tumor progression; Hedgehog; Metastasis; Signal transduction; Cancer; Phenotype; Immunology; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009282468,0.0002082708,0.0001263523,0.0002791822,0.0001319897,0.0001924415,0.00009587961,0.0001345536,0.0009125007],"category_scores_gemma":[0.0001040447,0.0001344819,0.0001197794,0.000100848,0.0002185444,0.0001259519,0.0001850931,0.0002203812,0.0002447732],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002819685,"about_ca_system_score_gemma":0.0001207402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004214077,"about_ca_topic_score_gemma":0.001090852,"domain_scores_codex":[0.9999323,0.00001222112,0.000006240725,0.00001933859,0.00001910452,0.0000108873],"domain_scores_gemma":[0.9999123,0.00001311804,0.00003135083,0.000009130095,0.00000542956,0.00002863337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001311441,0.000005987117,0.001218025,0.00001648496,0.000002137732,0.0001724138,0.000005276366,0.00003508055,0.9973469,0.00007958703,0.00003266419,0.000954234],"study_design_scores_gemma":[0.00003036623,0.0004774188,0.09566205,0.00001330395,0.00003071445,0.004560411,0.00005588955,0.0008578677,0.8925439,0.0002365467,0.005523105,0.000008415944],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946849,0.001686656,0.001258352,0.00009109443,0.00001446401,0.00001048825,0.0004946469,0.0001175141,0.001641916],"genre_scores_gemma":[0.9973653,0.0005871564,0.0009673342,0.00002944901,0.000007154683,0.00001055943,0.000252482,0.0000213666,0.0007591512],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009125007,"threshold_uncertainty_score":0.003052592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007326994176017889,"score_gpt":0.2347044440010213,"score_spread":0.2273774498250034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}