{"id":"W2153018276","doi":"10.1074/jbc.r112.349068","title":"Ryanodine Receptors: Structure and Function","year":2012,"lang":"en","type":"review","venue":"Journal of Biological Chemistry","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":288,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Michael Smith Health Research BC; Canadian Institutes of Health Research; Heart and Stroke Foundation of British Columbia and Yukon; Heart and Stroke Foundation of Canada","keywords":"Endoplasmic reticulum; Ryanodine receptor; Cell biology; Cytoplasm; Transmembrane protein; Transmembrane domain; Biology; Ion channel; Receptor; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002123348,0.0002579108,0.0006024656,0.00003212448,0.00004397684,0.00001927026,0.0001257656,0.000908087,0.0003227859],"category_scores_gemma":[0.0001138426,0.0001605621,0.0003079002,0.00007579593,0.00007820845,0.000004691462,0.00007277997,0.0003409036,0.000003270388],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000270149,"about_ca_system_score_gemma":0.00006480255,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":1.325875e-7,"about_ca_topic_score_gemma":4.149313e-8,"domain_scores_codex":[0.9989501,0.00006862231,0.0005010166,0.0002013377,0.000114399,0.0001645077],"domain_scores_gemma":[0.9989454,0.0000204352,0.0006335066,0.0001357056,0.0001190067,0.000145976],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001287209,0.00006479961,0.00005816866,0.002022439,0.0002701321,0.000002797754,0.000004705433,0.000001468426,0.01623486,0.000005625644,0.003568635,0.9776376],"study_design_scores_gemma":[0.0001660144,0.0001870256,0.00001135184,0.0003258928,0.0002107125,0.0004916606,0.000008630901,4.048795e-7,0.002654136,0.0000231146,0.9957392,0.0001818363],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002135064,0.9965759,0.0001562578,0.0000136231,0.0008519811,0.00007445151,0.00002022026,0.000005153596,0.0001673301],"genre_scores_gemma":[0.003386314,0.9909635,0.0001060644,0.00003222441,0.004671556,0.000002340931,0.0003113394,0.00001787288,0.000508824],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9921706,"threshold_uncertainty_score":0.7003999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04198011304210669,"score_gpt":0.2849726523645053,"score_spread":0.2429925393223986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}