{"id":"W2153018276","doi":"10.1074/jbc.r112.349068","title":"Ryanodine Receptors: Structure and Function","year":2012,"lang":"en","type":"review","venue":"Journal of Biological Chemistry","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":288,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Michael Smith Health Research BC; Canadian Institutes of Health Research; Heart and Stroke Foundation of British Columbia and Yukon; Heart and Stroke Foundation of Canada","keywords":"Endoplasmic reticulum; Ryanodine receptor; Cell biology; Cytoplasm; Transmembrane protein; Transmembrane domain; Biology; Ion channel; Receptor; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004169187,0.0008800995,0.001210741,0.001107815,0.0002909273,0.0009885145,0.001025445,0.001098327,0.002668622],"category_scores_gemma":[0.0004067425,0.0002528804,0.0002778073,0.001384827,0.0005766153,0.001260882,0.0006812902,0.001534274,0.003648404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006553858,"about_ca_system_score_gemma":0.0008214051,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007042526,"about_ca_topic_score_gemma":0.0006547325,"domain_scores_codex":[0.9998378,0.00001880027,0.00002108298,0.0000387462,0.00006562068,0.00001788485],"domain_scores_gemma":[0.9998653,0.00003372217,0.00002236859,0.00000736554,0.00004738431,0.00002373842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006767919,0.00004739688,0.0001476083,0.008564954,0.00003912267,0.0001943671,0.00006147147,0.0004591623,0.01032053,0.006110006,0.03489967,0.939088],"study_design_scores_gemma":[0.00000936673,0.00004674744,0.0005885772,0.0008385504,0.00003028125,0.0008959542,0.00002990404,0.00006976185,0.001113284,0.002337193,0.9940268,0.00001356027],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002050786,0.9975431,0.0003675571,0.0002568433,0.0002086761,0.000005729376,0.00003180224,0.00001582743,0.001365386],"genre_scores_gemma":[0.001518149,0.9960085,0.0003972223,0.0001581285,0.0002341722,0.00001002716,0.00006866289,0.000003366462,0.001601761],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002668622,"threshold_uncertainty_score":0.008927405,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04198011304210669,"score_gpt":0.2849726523645053,"score_spread":0.2429925393223986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}