{"id":"W2153021389","doi":"10.1128/mcb.00361-08","title":"Regulation of Multiple Core Spliceosomal Proteins by Alternative Splicing-Coupled Nonsense-Mediated mRNA Decay","year":2008,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":207,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Cancer Institute; National Institutes of Health; Genome Canada; Ontario Genomics; National Institute of General Medical Sciences; Ontario Genomics Institute","keywords":"Biology; Nonsense-mediated decay; Spliceosome; Gene knockdown; RNA splicing; Alternative splicing; Genetics; Intron; Gene; RNA-binding protein; Splicing factor; Exon; Computational biology; Cell biology; Messenger RNA; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001810881,0.0002256742,0.0002835476,0.00008481793,0.0001322321,0.000007419071,0.0001819542,0.0002572444,0.00001763471],"category_scores_gemma":[0.000138119,0.0002080989,0.0001084593,0.0001290745,0.0003523878,0.000004641443,0.0001360085,0.0001402345,0.000006808738],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001246429,"about_ca_system_score_gemma":0.00006880891,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003871689,"about_ca_topic_score_gemma":0.00003368319,"domain_scores_codex":[0.9985155,0.0001252934,0.0003116878,0.0004989284,0.0001536019,0.0003949258],"domain_scores_gemma":[0.9991573,0.00003466045,0.0001495648,0.0003560307,0.000144133,0.0001583165],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002296074,0.00007780713,0.01016103,0.00001958022,0.00008782384,0.00002920401,0.00004489984,0.00002798751,0.9887755,0.0001396911,0.0001237311,0.0002831557],"study_design_scores_gemma":[0.001327562,0.000660273,0.001612385,0.00001272947,0.00001353627,0.00005511319,0.0000250826,0.003384429,0.9914878,0.00006150494,0.001133479,0.0002260758],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9768431,0.001540804,0.02081863,0.00007273113,0.00004604493,0.0004394464,0.00005080073,0.0000144695,0.0001739763],"genre_scores_gemma":[0.9976798,0.000213338,0.0006003692,0.0001118441,0.00006344511,0.00003367764,0.0007799503,0.00003117309,0.0004863947],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02083671,"threshold_uncertainty_score":0.8486026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01270913837522509,"score_gpt":0.2432158412777096,"score_spread":0.2305067029024845,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}