{"id":"W2153029275","doi":"10.1126/science.1112125","title":"Mitochondrial DNA Mutations, Oxidative Stress, and Apoptosis in Mammalian Aging","year":2005,"lang":"en","type":"article","venue":"Science","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2155,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Center for Research Resources; National Institute of General Medical Sciences; National Institute on Aging","keywords":"Mitochondrial DNA; Biology; Oxidative stress; Mitochondrion; Mutation; Apoptosis; Genetics; DNA damage; Cell biology; DNA repair; Molecular biology; DNA; Oxidative phosphorylation; Polymerase; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003173203,0.0002562306,0.0001864242,0.0007196807,0.0001884329,0.0002816922,0.0001273079,0.0003114339,0.0002945508],"category_scores_gemma":[0.0002257833,0.00008453248,0.00009342204,0.0002133352,0.0004293967,0.0003359482,0.000238065,0.0002940311,0.00008279538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003193235,"about_ca_system_score_gemma":0.0001687971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002388585,"about_ca_topic_score_gemma":0.0004155233,"domain_scores_codex":[0.9999224,0.00002371135,0.000007315659,0.00001190375,0.00002347707,0.00001123822],"domain_scores_gemma":[0.9998478,0.00002138892,0.00006439968,0.000008057522,0.000019246,0.0000391584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003989875,0.0006157224,0.0594965,0.001143184,0.0001676495,0.00679295,0.0004915361,0.001694581,0.7233722,0.01493916,0.002110798,0.1851857],"study_design_scores_gemma":[0.0003431136,0.006375086,0.5437961,0.0004675086,0.000411239,0.0330158,0.0006025427,0.003718193,0.3287784,0.03249565,0.04990356,0.00009274607],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8368891,0.1564147,0.002265204,0.0009229527,0.0001146475,0.00002066607,0.00008991756,0.00005262621,0.003230086],"genre_scores_gemma":[0.9559377,0.04173373,0.0008247195,0.0001688986,0.0001221541,0.0000115356,0.00007141869,0.000002506816,0.00112725],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007196807,"threshold_uncertainty_score":0.002316833,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01021134385864043,"score_gpt":0.2626039677327144,"score_spread":0.252392623874074,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}