{"id":"W2153043341","doi":"10.1021/ol5004725","title":"Cysteine Pseudoprolines for Thiol Protection and Peptide Macrocyclization Enhancement in Fmoc-Based Solid-Phase Peptide Synthesis","year":2014,"lang":"en","type":"article","venue":"Organic Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Generalitat de Catalunya; CNIB","keywords":"Chemistry; Peptide; Cysteine; Thiol; Combinatorial chemistry; Peptide synthesis; Solid-phase synthesis; Phase (matter); Stereochemistry; Organic chemistry; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002205092,0.0001442352,0.0001800482,0.0000499656,0.00007522719,0.0000335013,0.00008093433,0.00008454297,0.0000229569],"category_scores_gemma":[0.0003169931,0.0001311469,0.0000723271,0.0000883523,0.00003935228,0.000004831596,0.00002730319,0.00004368176,0.000003350447],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002916979,"about_ca_system_score_gemma":0.00001574218,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002186942,"about_ca_topic_score_gemma":0.00005850915,"domain_scores_codex":[0.9990969,0.00005044332,0.0002289723,0.0003446449,0.00008548436,0.0001936089],"domain_scores_gemma":[0.9996089,0.00003607268,0.00009483212,0.0001853977,0.0000322086,0.00004257387],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007595253,0.00007518008,0.0002724096,0.00005625632,0.00002715373,3.883739e-7,0.00001229109,0.00004390838,0.995919,0.000003078937,0.0002810235,0.003233329],"study_design_scores_gemma":[0.0008943822,0.0001005577,0.00009787359,0.00003932029,0.00004670185,0.000001947864,0.000009678737,0.004551418,0.9911327,0.00001273366,0.002943391,0.0001692479],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8831483,0.00003108159,0.1142843,0.002226763,0.00002130197,0.000259874,0.000005719321,0.00001034592,0.00001232486],"genre_scores_gemma":[0.9973649,0.00001926556,0.0009819771,0.001141174,0.0002042904,0.0001646027,0.00005509282,0.00002397831,0.00004475111],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1142165,"threshold_uncertainty_score":0.5348015,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007192976311335063,"score_gpt":0.2517242646817437,"score_spread":0.2445312883704086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}