{"id":"W2153044109","doi":"10.1124/jpet.103.063453","title":"Gastric Tolerability and Prolonged Prostaglandin Inhibition in the Brain with a Nitric Oxide-Releasing Flurbiprofen Derivative, NCX-2216 [3-[4-(2-Fluoro-α-methyl-[1,1′-biphenyl]-4-acetyloxy)-3-methoxyphenyl]-2-propenoic acid 4-nitrooxy butyl ester]","year":2004,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Chemistry; Flurbiprofen; Pharmacology; Prostaglandin; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001265779,0.0003507522,0.0006504739,0.0002828926,0.0002372571,0.00005237481,0.0001074441,0.0001888088,0.00002437065],"category_scores_gemma":[0.00004231655,0.0002190641,0.00008754839,0.000431271,0.0004280032,0.0003319186,0.00005789247,0.0009212106,0.000001623861],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002658001,"about_ca_system_score_gemma":0.0002598563,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001404535,"about_ca_topic_score_gemma":0.00000352418,"domain_scores_codex":[0.9975322,0.0006794304,0.000669962,0.0003011459,0.0003801107,0.0004370749],"domain_scores_gemma":[0.9988612,0.0002547238,0.0004485374,0.0001400061,0.0001333733,0.0001621822],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005695548,0.0007996042,0.018428,0.0001383552,0.0002109205,0.0003993948,0.004988713,0.00001994851,0.9674512,0.00002740106,0.00003886483,0.00180203],"study_design_scores_gemma":[0.02005783,0.005054557,0.04234238,0.0002558992,0.0003637435,0.003774576,0.003352349,0.0001099325,0.9236788,0.0002733333,0.0004039038,0.0003327783],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903888,0.005429008,0.0003018074,0.002364003,0.0001455264,0.001311631,0.000003649621,0.00001888191,0.00003672277],"genre_scores_gemma":[0.9930569,0.0002348266,0.002518756,0.003829715,0.0002406267,0.00006938935,0.000004748099,0.00003490688,0.00001013039],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04377249,"threshold_uncertainty_score":0.8933176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01913001176003224,"score_gpt":0.3117397675970456,"score_spread":0.2926097558370134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}