{"id":"W2153075644","doi":"10.2337/db15-0399","title":"ACE2 Deficiency Worsens Epicardial Adipose Tissue Inflammation and Cardiac Dysfunction in Response to Diet-Induced Obesity","year":2015,"lang":"en","type":"article","venue":"Diabetes","topic":"Cardiovascular Disease and Adiposity","field":"Medicine","cited_by":260,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institutes of Health; Canadian Institutes of Health Research; Alberta Innovates; Alberta Innovates - Health Solutions; Heart and Stroke Foundation of Canada","keywords":"Lipotoxicity; Internal medicine; Endocrinology; Insulin resistance; Proinflammatory cytokine; Medicine; Steatosis; Inflammation; Heart failure; Adipose tissue; Adiponectin; Angiotensin II; Adipocyte; Cardiac function curve; Obesity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001921,0.0005131818,0.0004785946,0.0001994521,0.0001006104,0.0002551166,0.0001295216,0.0002180081,0.0009072566],"category_scores_gemma":[0.0001415349,0.0001413111,0.0002166337,0.0001099066,0.0002092174,0.0001507491,0.0001526376,0.0005612915,0.000132813],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009412885,"about_ca_system_score_gemma":0.0001140592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001700941,"about_ca_topic_score_gemma":0.000344783,"domain_scores_codex":[0.9999037,0.00002253647,0.00001184233,0.00001959631,0.00001879128,0.0000235039],"domain_scores_gemma":[0.9998636,0.000009230533,0.00003602558,0.00001093192,0.000007707104,0.00007247806],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003334083,0.0003191237,0.003741827,0.00008204409,0.00005239706,0.0004235083,0.00002219363,0.00006604988,0.9876118,0.00007629532,0.0001464776,0.004124179],"study_design_scores_gemma":[0.0006829694,0.007086901,0.2675481,0.00005521034,0.0003450485,0.005181491,0.0002124647,0.002507911,0.7105055,0.0004455017,0.005396088,0.0000326947],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966795,0.00151723,0.0008267227,0.0001102384,0.00003729657,0.00001115094,0.0001119392,0.0000465313,0.0006594374],"genre_scores_gemma":[0.9960018,0.001173947,0.0007672613,0.0001264586,0.00003376073,0.0000243369,0.0002052691,0.00001574855,0.001651504],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009072566,"threshold_uncertainty_score":0.003035009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01412787143060297,"score_gpt":0.2472461682112019,"score_spread":0.2331182967805989,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}