{"id":"W2153089127","doi":"10.1093/carcin/bgp300","title":"Hypomethylation and genome instability in the germline of exposed parents and their progeny is associated with altered miRNA expression","year":2009,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge","funders":"","keywords":"Biology; Germline; DNA methylation; Epigenetics; Genome instability; Methylation; Genetics; Somatic cell; Epigenome; microRNA; DNA damage; DNA; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003299176,0.0001226416,0.0001507137,0.00004448618,0.00004959638,0.00001274454,0.00007974054,0.0001000881,0.000001980145],"category_scores_gemma":[0.00008806672,0.0000793913,0.0000289667,0.000122217,0.00005605442,0.000006343531,0.00002812259,0.00004029397,5.441317e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000911905,"about_ca_system_score_gemma":0.00002276519,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001235356,"about_ca_topic_score_gemma":0.00002452932,"domain_scores_codex":[0.9991721,0.0001417131,0.0002030248,0.0002542777,0.0001013413,0.0001275701],"domain_scores_gemma":[0.9994949,0.00003159105,0.0001179863,0.0002350319,0.00008257661,0.00003788641],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00006198743,0.00006253763,0.1401776,0.00001029638,0.00001023526,3.424238e-7,0.0005461815,0.000008375448,0.8558554,0.0000014852,0.000001036231,0.003264497],"study_design_scores_gemma":[0.0003680135,0.0002535491,0.5301192,0.000009925143,0.000008026733,6.616564e-7,0.00008295584,0.00002930256,0.468953,0.0000751812,0.00003758112,0.00006252682],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945383,0.004848247,0.0001750497,0.00006408919,0.00001210104,0.0002893891,0.00003080643,0.000003242176,0.00003879576],"genre_scores_gemma":[0.9992289,0.0004018685,0.0001420541,0.00008266419,0.00002644337,0.00001216251,0.00009136971,0.000007985925,0.000006551717],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3899416,"threshold_uncertainty_score":0.3237483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01974873244406047,"score_gpt":0.2393525549674473,"score_spread":0.2196038225233868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}