{"id":"W2153090506","doi":"10.1371/journal.pone.0027538","title":"M5 Muscarinic Receptors Mediate Striatal Dopamine Activation by Ventral Tegmental Morphine and Pedunculopontine Stimulation in Mice","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Nipissing University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Ventral tegmental area; Nucleus accumbens; Dopamine; Pedunculopontine Tegmental Nucleus; Chemistry; Endocrinology; Pedunculopontine nucleus; Internal medicine; Muscarinic acetylcholine receptor; Muscarinic acetylcholine receptor M4; Dopamine receptor; Mesolimbic pathway; Neuroscience; Pharmacology; Dopaminergic; Biology; Cholinergic; Receptor; Medicine; Deep brain stimulation; Parkinson's disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004238621,0.001027731,0.0005190082,0.001283265,0.0004267335,0.0007454228,0.00091537,0.00137374,0.002353513],"category_scores_gemma":[0.0002276748,0.0008610504,0.000977498,0.0002219171,0.000938957,0.0006401894,0.0005552121,0.00255151,0.001143577],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001343174,"about_ca_system_score_gemma":0.0005640445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00235931,"about_ca_topic_score_gemma":0.005182669,"domain_scores_codex":[0.9992736,0.0001012178,0.00009423165,0.0001799164,0.0001548041,0.0001961386],"domain_scores_gemma":[0.999586,0.00002759028,0.0001751197,0.00003333811,0.00002754627,0.0001503434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004346132,0.0001209317,0.00037592,0.00004831972,0.00001667264,0.0001439725,0.00005163459,0.00007176598,0.9970642,0.0003447199,0.0001149254,0.001212326],"study_design_scores_gemma":[0.000200227,0.001549946,0.01227554,0.00006038047,0.0001023629,0.0008225209,0.0001867802,0.00163425,0.9776104,0.0002849234,0.005248924,0.0000238384],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875755,0.002451209,0.004811663,0.0006342418,0.00009586744,0.0001284553,0.00146755,0.0002728658,0.002562595],"genre_scores_gemma":[0.9774905,0.002212032,0.005664625,0.0003837405,0.00003894415,0.0004251695,0.001442521,0.0001051947,0.01223723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00235931,"threshold_uncertainty_score":0.009745479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02707508479215157,"score_gpt":0.2104029669421921,"score_spread":0.1833278821500406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}