{"id":"W2153109174","doi":"10.1128/iai.00785-12","title":"Altered Toll-Like Receptor 9 Signaling in Mycobacterium avium subsp. paratuberculosis-Infected Bovine Monocytes Reveals Potential Therapeutic Targets","year":2012,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Mycobacterium research and diagnosis","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Luonnontieteiden ja Tekniikan Tutkimuksen Toimikunta; Beef Cattle Research Council","keywords":"Paratuberculosis; Biology; TLR9; Microbiology; Mycobacterium; Immune system; Toll-Like Receptor 9; Innate immune system; Immunology; Bacteria; Gene; Genetics; Gene expression; DNA methylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001137554,0.0001436478,0.0002060058,0.00006352989,0.00009352919,0.0001945974,0.00008574108,0.000300437,0.001020837],"category_scores_gemma":[0.00007490392,0.00006690345,0.000116043,0.00006110917,0.00007920335,0.00008634455,0.00009593037,0.0003448604,0.0002795919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000143323,"about_ca_system_score_gemma":0.0001095054,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001882149,"about_ca_topic_score_gemma":0.0003289297,"domain_scores_codex":[0.9999119,0.00002188677,0.000006603188,0.000009750693,0.00001360244,0.00003626749],"domain_scores_gemma":[0.9999723,0.000005895125,0.000006452074,0.000002692044,0.000004458081,0.000008265268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006065597,0.00005707189,0.0005167719,0.00008906961,0.000004590561,0.0001690879,0.00002140898,0.0000479235,0.9944417,0.00004279336,0.00004637691,0.00395657],"study_design_scores_gemma":[0.0002037761,0.004841401,0.04588994,0.00005011999,0.00007805718,0.002573467,0.000228203,0.002121947,0.934242,0.0002794567,0.009476421,0.00001520043],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866802,0.009753193,0.001898984,0.0002772911,0.00006623763,0.00003138186,0.0001520012,0.00003534881,0.00110537],"genre_scores_gemma":[0.9963153,0.001904153,0.0007659026,0.0001016354,0.00001210181,0.00002342632,0.0001235398,0.000002741462,0.0007512345],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001020837,"threshold_uncertainty_score":0.003415108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0251852431898021,"score_gpt":0.2945222265550346,"score_spread":0.2693369833652325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}