{"id":"W2153109174","doi":"10.1128/iai.00785-12","title":"Altered Toll-Like Receptor 9 Signaling in Mycobacterium avium subsp. paratuberculosis-Infected Bovine Monocytes Reveals Potential Therapeutic Targets","year":2012,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Mycobacterium research and diagnosis","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Luonnontieteiden ja Tekniikan Tutkimuksen Toimikunta; Beef Cattle Research Council","keywords":"Paratuberculosis; Biology; TLR9; Microbiology; Mycobacterium; Immune system; Toll-Like Receptor 9; Innate immune system; Immunology; Bacteria; Gene; Genetics; Gene expression; DNA methylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007473842,0.0002688684,0.0004384362,0.0003122794,0.0002134142,0.00008639637,0.00006539271,0.0002059324,0.001285069],"category_scores_gemma":[0.0002426441,0.000238628,0.0001292041,0.0004016546,0.00008493666,0.0005062157,0.0000881104,0.0005900573,0.0001093912],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001516318,"about_ca_system_score_gemma":0.0000637109,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001270883,"about_ca_topic_score_gemma":0.00005454853,"domain_scores_codex":[0.9979447,0.0004964693,0.0004235393,0.0002462688,0.0002381298,0.0006509025],"domain_scores_gemma":[0.998831,0.0001701364,0.0001108506,0.0003398847,0.0001634486,0.0003846925],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005443183,0.0006200282,0.5929672,0.0001370601,0.00009686909,0.000004193267,0.0003209348,0.000001624345,0.4018339,0.00001578918,0.0008955786,0.002562483],"study_design_scores_gemma":[0.001831681,0.0005880076,0.9525843,0.0001246519,0.00009467482,0.00008159564,0.00007853574,0.00007951055,0.03811972,0.00003890194,0.00611407,0.0002644123],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951167,0.002430978,0.00009451007,0.0003112573,0.0008682119,0.0005576526,0.00001930083,0.000121493,0.0004798737],"genre_scores_gemma":[0.9963487,0.002108452,0.0000979849,0.0004741953,0.0004692979,0.0000881559,0.0002132984,0.0000319103,0.0001680446],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3637142,"threshold_uncertainty_score":0.9996279,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0251852431898021,"score_gpt":0.2945222265550346,"score_spread":0.2693369833652325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}