{"id":"W2153122962","doi":"10.1128/mcb.20.16.5865-5878.2000","title":"Regulation of c-SRC Activity and Function by the Adapter Protein CAS","year":2000,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":129,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"National Cancer Institute; U.S. Department of Health and Human Services; National Institutes of Health; Thomas F. and Kate Miller Jeffress Memorial Trust; National Science Foundation","keywords":"Proto-oncogene tyrosine-protein kinase Src; Biology; SH2 domain; SH3 domain; Cortactin; Tyrosine phosphorylation; Tyrosine kinase; Phosphorylation; Cell biology; Paxillin; Tyrosine-protein kinase CSK; Tyrosine; Kinase; Protein tyrosine phosphatase; Signal transducing adaptor protein; Signal transduction; Focal adhesion; Biochemistry; Cell; Cytoskeleton","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001627731,0.00008689706,0.0001441392,0.00003690973,0.00005191194,0.000006405072,0.00003359764,0.0001112808,0.0002665641],"category_scores_gemma":[0.00001560069,0.00005881193,0.00003773858,0.00007740273,0.0001907736,0.0000151767,0.00003055253,0.000126581,0.000007197676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009636426,"about_ca_system_score_gemma":0.00001764071,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001049822,"about_ca_topic_score_gemma":0.000003274335,"domain_scores_codex":[0.9992992,0.0001430854,0.0001082101,0.0002095804,0.0001023093,0.0001375746],"domain_scores_gemma":[0.9996598,0.00001776163,0.00003053488,0.0001985242,0.000034998,0.00005838684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002750485,0.00003499297,0.0003168088,0.00002355428,0.00002486532,0.000006667631,0.00002495257,6.187295e-7,0.9265893,0.0001964494,0.00006609792,0.07244069],"study_design_scores_gemma":[0.000633591,0.0005742952,0.006889892,0.00001157516,0.00003876703,0.00002912789,0.00001418293,0.0003766551,0.9792097,0.0004697899,0.01168463,0.00006780776],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922667,0.001512763,0.00336597,0.0006982803,0.000009504512,0.0003813311,0.000003296591,0.00000914317,0.001753003],"genre_scores_gemma":[0.9978758,0.00004954406,0.00006677942,0.0001560441,0.00001462972,0.00001506762,0.00003043752,0.000009862189,0.001781899],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07237288,"threshold_uncertainty_score":0.291869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01034046470280268,"score_gpt":0.2484148107650253,"score_spread":0.2380743460622226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}