{"id":"W2153122962","doi":"10.1128/mcb.20.16.5865-5878.2000","title":"Regulation of c-SRC Activity and Function by the Adapter Protein CAS","year":2000,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":129,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"National Cancer Institute; U.S. Department of Health and Human Services; National Institutes of Health; Thomas F. and Kate Miller Jeffress Memorial Trust; National Science Foundation","keywords":"Proto-oncogene tyrosine-protein kinase Src; Biology; SH2 domain; SH3 domain; Cortactin; Tyrosine phosphorylation; Tyrosine kinase; Phosphorylation; Cell biology; Paxillin; Tyrosine-protein kinase CSK; Tyrosine; Kinase; Protein tyrosine phosphatase; Signal transducing adaptor protein; Signal transduction; Focal adhesion; Biochemistry; Cell; Cytoskeleton","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001128555,0.0003520843,0.0001788821,0.0001991991,0.000181561,0.0004349849,0.0002928525,0.0002511791,0.000690081],"category_scores_gemma":[0.0001410125,0.0001149177,0.0002376951,0.0001699116,0.0002662823,0.0002351165,0.0002099774,0.000478876,0.000204481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005630109,"about_ca_system_score_gemma":0.0002338221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001092544,"about_ca_topic_score_gemma":0.001149183,"domain_scores_codex":[0.9998331,0.00002150334,0.00001755762,0.00003395841,0.0000486468,0.00004527691],"domain_scores_gemma":[0.999879,0.00002187222,0.00003910834,0.00001488624,0.00001857091,0.00002649744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005212512,0.000008159364,0.0002305222,0.00002651527,0.000004166322,0.00006679741,0.000008176642,0.00005203234,0.9982532,0.0002163046,0.00002965947,0.001052428],"study_design_scores_gemma":[0.00002164782,0.00007864141,0.008355226,0.000006820768,0.00001799465,0.0005874875,0.00003712908,0.002706569,0.9842616,0.00008724806,0.003832731,0.000007043499],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899031,0.004593017,0.00335189,0.0001369746,0.00003561765,0.0000252421,0.0002327693,0.0000653444,0.001656032],"genre_scores_gemma":[0.996331,0.001176675,0.001414644,0.00002917184,0.000007621883,0.00001645333,0.0002207886,0.000008945402,0.0007947197],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001092544,"threshold_uncertainty_score":0.004084945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01034046470280268,"score_gpt":0.2484148107650253,"score_spread":0.2380743460622226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}