{"id":"W2153132143","doi":"10.1002/jcph.526","title":"Evaluation of the effect of food and gastric pH on the single‐dose pharmacokinetics of cabozantinib in healthy adult subjects","year":2015,"lang":"en","type":"article","venue":"The Journal of Clinical Pharmacology","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"Celerion (Canada)","funders":"Exelixis","keywords":"Cabozantinib; Pharmacokinetics; Esomeprazole; Bioavailability; Tyrosine-kinase inhibitor; Medicine; Pharmacology; Medullary thyroid cancer; Gastroenterology; Concomitant; Drug interaction; Internal medicine; Drug; Cancer; Thyroid cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01325412,0.0001462885,0.0007922614,0.0001078234,0.00002381279,0.000001432897,0.0002745253,0.0001047903,0.00004954827],"category_scores_gemma":[0.004828752,0.00006399392,0.0001824802,0.0003202069,0.0004333563,0.00003064127,0.00007916867,0.0007574206,0.000001217587],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001873052,"about_ca_system_score_gemma":0.001054374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002214836,"about_ca_topic_score_gemma":0.00001157122,"domain_scores_codex":[0.9926406,0.004597454,0.001522884,0.0001129526,0.0009303235,0.0001957864],"domain_scores_gemma":[0.9911876,0.00586169,0.001787333,0.0002330019,0.000796198,0.0001342281],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.2050922,0.01068479,0.2760863,0.001200128,0.00611242,0.00007508352,0.004697,0.007036682,0.2835727,0.0001006461,0.02198963,0.1833524],"study_design_scores_gemma":[0.1995417,0.09735869,0.1992869,0.0009034323,0.01236779,0.000586804,0.0003807175,0.007385173,0.4810426,0.0005574769,0.000390398,0.0001983024],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927823,0.001305646,0.000002906667,0.003699519,0.0009562403,0.0009373694,0.000006363934,0.000002062262,0.0003075836],"genre_scores_gemma":[0.9981553,0.0006596905,0.00002180136,0.0008031139,0.0003342797,0.000005136259,5.205317e-7,0.0000133212,0.000006864474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1974699,"threshold_uncertainty_score":0.5780817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1295850874211154,"score_gpt":0.4499434924723286,"score_spread":0.3203584050512132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}