{"id":"W2153228512","doi":"10.1002/pro.503","title":"Phenotypic effects of Ehlers–Danlos syndrome‐associated mutation on the FnIII domain of tenascin‐X","year":2010,"lang":"en","type":"article","venue":"Protein Science","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lakehead University; University of British Columbia","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Michael Smith Health Research BC","keywords":"Ehlers–Danlos syndrome; Tenascin; Fibrillogenesis; Mutation; Phenotype; Point mutation; Extracellular matrix; Fibronectin; Mutant; Genetics; Biology; Chemistry; Gene; Fibril; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000522198,0.00006860888,0.00007893905,0.0000497942,0.0001145627,0.00001215666,0.0002923991,0.00005432441,0.00002094522],"category_scores_gemma":[0.0007561696,0.00004765206,0.00004963588,0.0002524449,0.0002235385,0.000006312924,0.0000676935,0.0001065139,0.000005136517],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008911399,"about_ca_system_score_gemma":0.00008518458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002546077,"about_ca_topic_score_gemma":0.00001932902,"domain_scores_codex":[0.999272,0.00003638666,0.0001360515,0.0001945164,0.0002233567,0.0001377211],"domain_scores_gemma":[0.9993432,0.00002884546,0.0001458539,0.0003024091,0.0001450973,0.00003463202],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00000793964,0.0000679359,0.00002582866,0.00001157714,0.000007581205,8.912689e-7,0.00004862383,0.000003533045,0.9950055,0.004317349,0.00001523349,0.0004879462],"study_design_scores_gemma":[0.0001489677,0.0003028296,0.0007626764,0.00003595627,0.000004692588,0.000005231515,0.00003584879,0.0002355961,0.9968793,0.001354098,0.0001777624,0.00005706422],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975636,0.00002413065,0.001142621,0.0001387576,0.0001598161,0.0003852567,0.000004862885,0.00000383365,0.000577137],"genre_scores_gemma":[0.9993812,0.000002265054,0.0003735597,0.0000392992,0.00001514474,0.00003515505,0.000004983789,0.000005546012,0.0001427978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002963252,"threshold_uncertainty_score":0.1943195,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004481619180868231,"score_gpt":0.2224838543503119,"score_spread":0.2180022351694437,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}