{"id":"W2153263227","doi":"10.1080/10739680601131218","title":"Abrupt Reoxygenation of Microvascular Endothelial Cells After Hypoxia Activates ERK1/2 and JNK1, Leading to NADPH Oxidase‐Dependent Oxidant Production","year":2007,"lang":"en","type":"article","venue":"Microcirculation","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"","keywords":"NADPH oxidase; p38 mitogen-activated protein kinases; MAPK/ERK pathway; Tyrosine phosphorylation; Phosphorylation; Kinase; Reactive oxygen species; Cell biology; Hypoxia (environmental); Mitochondrial ROS; Protein kinase A; Protein kinase C; Chemistry; Biology; Molecular biology; Oxygen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001424882,0.0004280528,0.0002539173,0.0001023784,0.0001483855,0.0001797649,0.000213622,0.0002362899,0.001240925],"category_scores_gemma":[0.00006802192,0.0001425555,0.0003864368,0.00009805283,0.0001745019,0.0002112137,0.0001841415,0.0005383467,0.0001967283],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001998451,"about_ca_system_score_gemma":0.0001378864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003698187,"about_ca_topic_score_gemma":0.0007180794,"domain_scores_codex":[0.9998803,0.00001153249,0.00001052727,0.00002640106,0.00003051906,0.00004069221],"domain_scores_gemma":[0.9999515,0.000004539744,0.0000202016,0.000006151342,0.000006000651,0.00001168625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001481228,0.00002904184,0.0002800633,0.00004714554,0.000008891835,0.00009692993,0.00001163313,0.00003115482,0.9985816,0.00003934735,0.00002950532,0.0006965919],"study_design_scores_gemma":[0.00002778815,0.0007086249,0.01403935,0.00001264232,0.00002685733,0.0004043131,0.00004765547,0.0005680817,0.9829928,0.00004026337,0.001126184,0.000005575148],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936122,0.001861804,0.003294266,0.0001078824,0.00004548992,0.00004210991,0.000198873,0.00007187149,0.0007655092],"genre_scores_gemma":[0.9953374,0.000965492,0.002062188,0.00005494693,0.00002150067,0.00005461014,0.0002517429,0.000007613504,0.00124438],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001240925,"threshold_uncertainty_score":0.004151344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00603302424871224,"score_gpt":0.2290078626912065,"score_spread":0.2229748384424942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}