{"id":"W2153263227","doi":"10.1080/10739680601131218","title":"Abrupt Reoxygenation of Microvascular Endothelial Cells After Hypoxia Activates ERK1/2 and JNK1, Leading to NADPH Oxidase‐Dependent Oxidant Production","year":2007,"lang":"en","type":"article","venue":"Microcirculation","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"","keywords":"NADPH oxidase; p38 mitogen-activated protein kinases; MAPK/ERK pathway; Tyrosine phosphorylation; Phosphorylation; Kinase; Reactive oxygen species; Cell biology; Hypoxia (environmental); Mitochondrial ROS; Protein kinase A; Protein kinase C; Chemistry; Biology; Molecular biology; Oxygen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005025929,0.0001918332,0.0002006971,0.0001535875,0.00008044385,0.00002672567,0.00008221671,0.000169393,0.00001151487],"category_scores_gemma":[0.00006038765,0.0002043807,0.0001017062,0.0001440999,0.00004750609,0.00001973055,0.00005595791,0.00008202664,0.000008949631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005636223,"about_ca_system_score_gemma":0.00004418576,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008261295,"about_ca_topic_score_gemma":0.0001176505,"domain_scores_codex":[0.9986404,0.00004462523,0.0003402811,0.0004970494,0.0002007239,0.0002769252],"domain_scores_gemma":[0.9992831,0.000009945622,0.0001494479,0.000290666,0.0001749064,0.00009197457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002122451,0.00004943303,0.0005659902,0.00004999686,0.00005605711,8.709997e-7,0.0003291615,0.0001619836,0.9863507,0.000008848947,0.0002430385,0.01197166],"study_design_scores_gemma":[0.000485701,0.00005611799,0.02652155,0.00002893339,0.00004967677,0.00003117622,0.00009425302,0.000006169186,0.9469437,0.0000240178,0.02553996,0.0002187491],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870154,0.001863802,0.009737326,0.0000617017,0.000752103,0.0004676443,0.00002288779,0.00001535522,0.0000638165],"genre_scores_gemma":[0.9962385,0.0002333417,0.001777082,0.0001237952,0.001082982,0.00002198009,0.00007273616,0.00003351305,0.0004160852],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03940703,"threshold_uncertainty_score":0.8334403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00603302424871224,"score_gpt":0.2290078626912065,"score_spread":0.2229748384424942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}