{"id":"W2153285246","doi":"10.1161/01.res.0000245189.21703.c0","title":"Adenylyl Cyclase Isoform–Selective Regulation of Vascular Smooth Muscle Proliferation and Cytoskeletal Reorganization","year":2006,"lang":"en","type":"article","venue":"Circulation Research","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Cell biology; Adenylyl cyclase; Forskolin; Protein kinase A; Signal transduction; Biology; Vascular smooth muscle; Gene isoform; MAPK/ERK pathway; Cytoskeleton; Phosphorylation; Gs alpha subunit; Phosphodiesterase; Receptor; Endocrinology; Biochemistry; Cell; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000105992,0.0002643701,0.0001449938,0.0001633606,0.0001577524,0.0002323999,0.0001196965,0.0001568042,0.001438468],"category_scores_gemma":[0.00007318886,0.0001351803,0.0002463174,0.000123013,0.0002056373,0.0001747657,0.0001560938,0.0005052909,0.0002154538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002450567,"about_ca_system_score_gemma":0.0001657371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005761717,"about_ca_topic_score_gemma":0.0009920998,"domain_scores_codex":[0.9998908,0.00001835531,0.000008100013,0.0000297132,0.00001940616,0.00003362871],"domain_scores_gemma":[0.999918,0.00001228824,0.00001889721,0.00001224557,0.000009601513,0.00002885921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005125372,0.00001083346,0.00003957337,0.00001096428,0.000001388942,0.00001006211,0.000005519045,0.00001244548,0.9994926,0.0000417264,0.00000977343,0.0003138504],"study_design_scores_gemma":[0.00001474878,0.0002049049,0.006888482,0.000003049573,0.00001016799,0.0001004029,0.00002705703,0.0007665026,0.9906535,0.00003446958,0.001292863,0.000003799413],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965793,0.001077972,0.0007064456,0.00004793784,0.00002535115,0.00001907079,0.0001459692,0.00003136982,0.001366566],"genre_scores_gemma":[0.9953462,0.000801177,0.001005233,0.00002727724,0.00001482279,0.00002353401,0.0002802793,0.000007858947,0.00249353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001438468,"threshold_uncertainty_score":0.004812181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01327584774451272,"score_gpt":0.2738825307444658,"score_spread":0.2606066829999531,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}