{"id":"W2153310447","doi":"10.1038/cr.2010.46","title":"Hypoxia induces PGC-1α expression and mitochondrial biogenesis in the myocardium of TOF patients","year":2010,"lang":"en","type":"article","venue":"Cell Research","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":100,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Mitochondrial biogenesis; Biology; Hypoxia (environmental); Myocyte; Mitochondrion; Biogenesis; Regulator; Tetralogy of Fallot; Endocrinology; Internal medicine; Cell biology; Organelle biogenesis; Coactivator; Gene; Transcription factor; Heart disease; Biochemistry; Medicine; Chemistry; Oxygen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001092897,0.0001838764,0.0003901991,0.0003135196,0.0002376754,0.0002484295,0.00008596482,0.0002654914,0.001270357],"category_scores_gemma":[0.0004309155,0.0001392388,0.0001354347,0.0001894195,0.0002297738,0.0001887798,0.0001197325,0.0002786642,0.0001245948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001293451,"about_ca_system_score_gemma":0.00008606095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002815948,"about_ca_topic_score_gemma":0.0002101849,"domain_scores_codex":[0.9999331,0.00001533126,0.000007408168,0.00001676102,0.00001207542,0.00001534557],"domain_scores_gemma":[0.9998276,0.00003620734,0.00005495158,0.00001060442,0.00001338057,0.00005727132],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01131932,0.0004002053,0.4579302,0.00008529986,0.00009815678,0.009580304,0.0006615964,0.0003234064,0.505081,0.000247501,0.0003854783,0.01388766],"study_design_scores_gemma":[0.00006411423,0.001833373,0.9630702,0.00001210298,0.00007164058,0.01203155,0.0005681379,0.0005964445,0.02109007,0.0002686385,0.0003820639,0.00001162393],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999658,0.00007367823,0.00009784677,0.0000174683,0.000003913109,0.000001189625,0.00003105851,0.000002092145,0.0001148058],"genre_scores_gemma":[0.9996518,0.00005283063,0.00005094602,0.00001320924,0.000011185,0.000003636764,0.00007719186,0.000002262419,0.0001368681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001270357,"threshold_uncertainty_score":0.004249752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02780246211785296,"score_gpt":0.3043224371840226,"score_spread":0.2765199750661697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}