{"id":"W2153315176","doi":"10.1128/iai.00328-12","title":"Impaired Innate Immunity in Mice Deficient in Interleukin-1 Receptor-Associated Kinase 4 Leads to Defective Type 1 T Cell Responses, B Cell Expansion, and Enhanced Susceptibility to Infection with Toxoplasma gondii","year":2012,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Toxoplasma gondii Research Studies","field":"Immunology and Microbiology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University and Génome Québec Innovation Centre","funders":"National Institutes of Health; National Institute of Allergy and Infectious Diseases; Universidade Federal de Minas Gerais","keywords":"Biology; Innate immune system; Immunology; Toxoplasma gondii; Immunity; Receptor; Immune system; Antibody; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002287153,0.001536823,0.0005267728,0.001255875,0.0002989202,0.0004409451,0.0004302553,0.000933957,0.003589173],"category_scores_gemma":[0.0003165866,0.0007020159,0.0006106348,0.0004612135,0.0006523973,0.0002384576,0.0004460976,0.001240862,0.000900466],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003291125,"about_ca_system_score_gemma":0.0002440442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005389754,"about_ca_topic_score_gemma":0.0007343171,"domain_scores_codex":[0.9995683,0.00009262832,0.00006976446,0.0001311067,0.00006944298,0.00006880395],"domain_scores_gemma":[0.9992861,0.00007413643,0.0003456407,0.00005741799,0.00002181292,0.0002148575],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007590514,0.0001286429,0.0007855395,0.00005314456,0.00003112434,0.0003219029,0.00004887192,0.0001128876,0.9967449,0.0001411847,0.00006126703,0.0008114504],"study_design_scores_gemma":[0.001199476,0.00362345,0.1039921,0.0001567268,0.0005410088,0.0112211,0.0003996748,0.004817673,0.8656395,0.001021828,0.007286227,0.0001012128],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957015,0.0003966877,0.001687412,0.0001092194,0.00003162309,0.00003769587,0.001206871,0.0002029029,0.0006260907],"genre_scores_gemma":[0.9890236,0.0006518438,0.003451555,0.0001202312,0.00003634339,0.0001332948,0.001471681,0.0001694497,0.004942114],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003589173,"threshold_uncertainty_score":0.012007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01551929824408086,"score_gpt":0.2705749067880215,"score_spread":0.2550556085439406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}