{"id":"W2153315176","doi":"10.1128/iai.00328-12","title":"Impaired Innate Immunity in Mice Deficient in Interleukin-1 Receptor-Associated Kinase 4 Leads to Defective Type 1 T Cell Responses, B Cell Expansion, and Enhanced Susceptibility to Infection with Toxoplasma gondii","year":2012,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Toxoplasma gondii Research Studies","field":"Immunology and Microbiology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University and Génome Québec Innovation Centre","funders":"National Institutes of Health; National Institute of Allergy and Infectious Diseases; Universidade Federal de Minas Gerais","keywords":"Biology; Innate immune system; Immunology; Toxoplasma gondii; Immunity; Receptor; Immune system; Antibody; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002121783,0.0003592227,0.0004784457,0.0007804862,0.0004501701,0.00004109873,0.0001114258,0.0003429755,0.00007682933],"category_scores_gemma":[0.001296549,0.000329717,0.00005062357,0.001305946,0.0002455402,0.0003413371,0.0004149192,0.001113091,0.0001351938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007362371,"about_ca_system_score_gemma":0.0001198351,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.01326101,"about_ca_topic_score_gemma":0.02458802,"domain_scores_codex":[0.9959399,0.00232632,0.0004555705,0.0004385594,0.0000846375,0.0007550719],"domain_scores_gemma":[0.9985045,0.0005802399,0.0001484234,0.0003533532,0.000283839,0.0001296181],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002298184,0.0009064561,0.3779344,0.00004211479,0.00002680791,8.830856e-7,0.006609701,0.00002621516,0.6112216,0.000005710611,0.0001129921,0.0008149218],"study_design_scores_gemma":[0.00166949,0.001665071,0.6201831,0.00008331394,0.00001376143,0.000009876609,0.00080779,0.00000159968,0.3745391,0.000007794617,0.0007585565,0.0002604859],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973342,0.0004931279,0.00007126819,0.00006233076,0.0004709546,0.001037781,0.00003254068,0.000101831,0.0003958951],"genre_scores_gemma":[0.9988849,0.0003286127,0.00004815376,0.00009414684,0.00001022934,0.000128285,0.00005723078,0.00002653483,0.0004218986],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2422487,"threshold_uncertainty_score":0.9999155,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01551929824408086,"score_gpt":0.2705749067880215,"score_spread":0.2550556085439406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}