{"id":"W2153356162","doi":"10.4161/cc.23058","title":"Mitochondrial dysfunction in breast cancer cells prevents tumor growth","year":2012,"lang":"en","type":"article","venue":"Cell Cycle","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"National Institute on Alcohol Abuse and Alcoholism","keywords":"Mitochondrion; Biology; Cancer cell; Metformin; Cancer; Cancer research; Mitochondrial ROS; Autophagy; Mitochondrial biogenesis; Breast cancer; DNAJA3; Oxidative phosphorylation; Biguanide; Stromal cell; Paracrine signalling; Cell biology; Mitochondrial DNA; Endocrinology; mitochondrial fusion; Apoptosis; Diabetes mellitus; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001261701,0.0002489117,0.0003072957,0.0002059756,0.0001991852,0.0002602723,0.0002187066,0.0003110488,0.001384397],"category_scores_gemma":[0.0001087811,0.0001061348,0.000201437,0.0002658108,0.0001198573,0.0001179484,0.0001571141,0.0006647342,0.0005669849],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003053932,"about_ca_system_score_gemma":0.0003214975,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001062123,"about_ca_topic_score_gemma":0.002051977,"domain_scores_codex":[0.9998688,0.00002392117,0.00001387494,0.00002516047,0.00003888329,0.00002952498],"domain_scores_gemma":[0.9999353,0.000009737298,0.00001563191,0.00001390458,0.00001081201,0.00001465312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003052528,0.0001426325,0.0002293617,0.0001099775,0.00001272004,0.00006195174,0.00003017925,0.00009562806,0.9913987,0.0002290605,0.0005434255,0.00684107],"study_design_scores_gemma":[0.00005019668,0.0008106056,0.003236735,0.0000141899,0.00002223792,0.000277266,0.0000340706,0.0006657052,0.9810431,0.00007100084,0.01377038,0.00000453457],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9739386,0.0111988,0.00455677,0.0009051448,0.0002844421,0.0001312138,0.001819615,0.0006161353,0.006549376],"genre_scores_gemma":[0.9830238,0.00541254,0.002975459,0.0002488617,0.00002509543,0.0001403732,0.001777359,0.00004222392,0.006354284],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001384397,"threshold_uncertainty_score":0.004631281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004707943433623323,"score_gpt":0.2158224249085149,"score_spread":0.2111144814748916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}