{"id":"W2153356162","doi":"10.4161/cc.23058","title":"Mitochondrial dysfunction in breast cancer cells prevents tumor growth","year":2012,"lang":"en","type":"article","venue":"Cell Cycle","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"National Institute on Alcohol Abuse and Alcoholism","keywords":"Mitochondrion; Biology; Cancer cell; Metformin; Cancer; Cancer research; Mitochondrial ROS; Autophagy; Mitochondrial biogenesis; Breast cancer; DNAJA3; Oxidative phosphorylation; Biguanide; Stromal cell; Paracrine signalling; Cell biology; Mitochondrial DNA; Endocrinology; mitochondrial fusion; Apoptosis; Diabetes mellitus; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008273262,0.0001267991,0.000122553,0.00003039505,0.00003430239,0.00001193253,0.0001116671,0.00008975105,0.0002827801],"category_scores_gemma":[0.000004921488,0.0001230175,0.00006355314,0.0000758883,0.00002653643,0.00001011269,0.00004848881,0.00007639898,0.00005455312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002652897,"about_ca_system_score_gemma":0.00004603964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001457056,"about_ca_topic_score_gemma":0.00002995227,"domain_scores_codex":[0.9991274,0.00005074726,0.000146889,0.0002253105,0.0001027879,0.0003469021],"domain_scores_gemma":[0.9996079,0.000003570074,0.00005969205,0.0001898074,0.0000302984,0.0001086957],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001026596,0.0002216721,0.01355558,0.00004519131,0.00001544428,9.08594e-7,0.00007209719,0.00003939004,0.9651459,0.000008884081,0.01281517,0.007977061],"study_design_scores_gemma":[0.0011151,0.00002661951,0.0139769,0.00001289816,0.00002338897,0.000002743742,0.0000323071,0.00001548628,0.9006713,0.00003570631,0.08387224,0.000215319],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9603807,0.03608845,0.00004821994,0.00001293069,0.001916109,0.0001490885,0.00004349867,0.000008490812,0.001352487],"genre_scores_gemma":[0.9919722,0.004915863,0.00009131355,0.0003878124,0.001917349,0.00007240324,0.00003388246,0.00002532065,0.000583849],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07105707,"threshold_uncertainty_score":0.5016508,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004707943433623323,"score_gpt":0.2158224249085149,"score_spread":0.2111144814748916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}