{"id":"W2153420410","doi":"10.15252/embr.201540121","title":"The second coming of epigenetic drugs","year":2015,"lang":"en","type":"article","venue":"EMBO Reports","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Epigenetics; Biology; Computational biology; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004044075,0.0007677411,0.0008961333,0.001578775,0.001716859,0.006894713,0.001217845,0.00637165,0.1158708],"category_scores_gemma":[0.009360209,0.0004551354,0.0009175101,0.0009343565,0.002948758,0.006076367,0.004219253,0.009222802,0.04294208],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002945793,"about_ca_system_score_gemma":0.003654153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00132372,"about_ca_topic_score_gemma":0.003082671,"domain_scores_codex":[0.9971635,0.000664158,0.0001880546,0.0003611054,0.0012109,0.0004122813],"domain_scores_gemma":[0.9939568,0.00121298,0.0003471361,0.000738349,0.001536942,0.002207795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007746807,0.00006055031,0.0002433353,0.0003549026,0.0000287106,0.0002025036,0.0001074596,0.00008068929,0.000951649,0.03492175,0.8278656,0.1351054],"study_design_scores_gemma":[0.00001058628,0.0000303353,0.0001442178,0.0001206459,0.000005873934,0.000113919,0.00003343037,0.00002731512,0.0002434849,0.005102073,0.9941614,0.000006712934],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"review","genre_scores_codex":[0.003494561,0.1482237,0.003319343,0.4659383,0.09854595,0.0001211595,0.001568295,0.001008845,0.2777799],"genre_scores_gemma":[0.034731,0.1034377,0.003116941,0.2572002,0.04936612,0.0002095524,0.001590594,0.0006134153,0.5497346],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.1158708,"threshold_uncertainty_score":0.3876265,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01161246330363717,"score_gpt":0.2458759014692902,"score_spread":0.234263438165653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}