{"id":"W2153420410","doi":"10.15252/embr.201540121","title":"The second coming of epigenetic drugs","year":2015,"lang":"en","type":"article","venue":"EMBO Reports","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Epigenetics; Biology; Computational biology; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003640725,0.00005723863,0.00006561817,0.00001087299,0.00004599324,0.00001144147,0.00006528275,0.00004866005,0.00001941891],"category_scores_gemma":[0.0001496011,0.00004162955,0.00004268847,0.00003664425,0.0000583836,0.000001555844,0.0000550553,0.00003378846,0.000003075339],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005682571,"about_ca_system_score_gemma":0.00008628877,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007841773,"about_ca_topic_score_gemma":0.00001701983,"domain_scores_codex":[0.9994029,0.00003075925,0.0002249613,0.0001297984,0.0001140347,0.00009759321],"domain_scores_gemma":[0.9993695,0.000006479408,0.0001518335,0.0003278675,0.00008536429,0.00005897695],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007057799,0.00008662952,0.01058917,0.00003328096,0.0001024383,0.0000476487,0.0004455344,0.00003616105,0.8118992,0.0004081204,0.1579741,0.01830712],"study_design_scores_gemma":[0.00007746532,0.00004585125,0.0003687633,0.000003237648,0.000002325226,0.00003378327,0.00008316871,0.000004821437,0.6184585,0.0003575723,0.3805176,0.00004683041],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9762201,0.001411935,0.0002089331,0.0001453801,0.0004077682,0.0001154947,0.000001547649,0.000006107138,0.02148276],"genre_scores_gemma":[0.9912038,0.0000162516,0.0001736177,0.00008472786,0.0001138729,0.000008457446,0.00001548719,0.000007677239,0.008376099],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2225435,"threshold_uncertainty_score":0.1697604,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01161246330363717,"score_gpt":0.2458759014692902,"score_spread":0.234263438165653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}