{"id":"W2153422966","doi":"10.1242/dev.02523","title":"Disruption of early proximodistal patterning and AVE formation in<i>Apc</i>mutants","year":2006,"lang":"en","type":"article","venue":"Development","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital","funders":"","keywords":"Epiblast; Biology; Endoderm; NODAL; Wnt signaling pathway; Gastrulation; Cell biology; Adenomatous polyposis coli; Embryonic stem cell; Nodal signaling; Primitive streak; Germ layer; Genetics; Embryogenesis; Gene; Embryo; Induced pluripotent stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001203779,0.00009040564,0.00008480518,0.00004700517,0.00003485262,0.00001349556,0.00005161029,0.00006129389,0.000007373446],"category_scores_gemma":[0.000005127493,0.00008768711,0.00001436166,0.00005542354,0.00002415345,0.000008418957,0.0000497641,0.00003541532,0.000002718017],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000263265,"about_ca_system_score_gemma":0.00004198149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002079919,"about_ca_topic_score_gemma":0.00005879845,"domain_scores_codex":[0.9993318,0.00001424904,0.0002486719,0.0001549952,0.0001136339,0.0001366676],"domain_scores_gemma":[0.9997978,0.000002828417,0.00008149387,0.00006086167,0.00003734411,0.0000196575],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001062659,0.00006383609,0.3063768,0.0000860345,0.0000213421,0.000005179426,0.001131172,0.00005238099,0.6724754,0.00005601248,0.0002445291,0.019381],"study_design_scores_gemma":[0.0004851588,0.00003910628,0.4323368,0.00005414005,0.000002951231,0.000006623057,0.00005823688,0.00003140521,0.5642385,0.0000709107,0.002519782,0.0001562965],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963886,0.0001713396,0.002753169,0.00001717696,0.00004866222,0.0001226959,0.000003030072,0.000005545372,0.0004898132],"genre_scores_gemma":[0.9975153,0.00002144086,0.001995558,0.00002295745,0.00003362456,0.00003031793,0.0001459853,0.000008317786,0.0002264655],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.12596,"threshold_uncertainty_score":0.3575777,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00795550496174697,"score_gpt":0.2185780037749592,"score_spread":0.2106224988132122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}