{"id":"W2153454059","doi":"10.1124/jpet.113.206805","title":"A Correlation between Cytotoxicity and Reductase-Mediated Metabolism in Cell Lines Treated with Doxorubicin and Daunorubicin","year":2013,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Cytotoxicity; Doxorubicin; Daunorubicin; Cell culture; Pharmacology; Metabolism; Viability assay; Toxicity; Cell; Chemistry; Biology; Biochemistry; In vitro; Immunology; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001768356,0.0001608894,0.0004048424,0.0001617116,0.0000596777,0.00001795361,0.00002600154,0.0001427605,0.00004268439],"category_scores_gemma":[0.00000330149,0.0001194687,0.00003224705,0.0001256542,0.0001819482,0.0002044137,0.00001519205,0.0003204401,9.322679e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004926059,"about_ca_system_score_gemma":0.0000443825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000324039,"about_ca_topic_score_gemma":0.000001051504,"domain_scores_codex":[0.9991549,0.0001026721,0.0003244907,0.0001410243,0.0001203537,0.0001565465],"domain_scores_gemma":[0.9994723,0.00009960371,0.0001941528,0.00004304384,0.00007347182,0.0001174315],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006603108,0.0001779976,0.01893616,0.00001958023,0.0001852781,0.00002297012,0.00125578,0.000004992803,0.9778841,0.000003852454,0.00006175704,0.0007872024],"study_design_scores_gemma":[0.007472824,0.0008377905,0.04378727,0.00003727126,0.000273734,0.0003553522,0.0008794079,0.0003780379,0.9456707,0.00003137538,0.0001622308,0.0001139774],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938577,0.0047185,0.00003346583,0.0008664834,0.00005862975,0.0003817403,0.000004146038,0.000009222529,0.00007014206],"genre_scores_gemma":[0.9970195,0.001168506,0.0003217917,0.001232932,0.0001892328,0.000008782671,0.000008726432,0.00001559843,0.00003497861],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03221339,"threshold_uncertainty_score":0.4871791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0190108903576302,"score_gpt":0.3005896731247698,"score_spread":0.2815787827671395,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}