{"id":"W2153455336","doi":"10.1074/jbc.m413239200","title":"Effect of CAT or AGG Interruptions and CpG Methylation on Nucleosome Assembly upon Trinucleotide Repeats on Spinocerebellar Ataxia, Type 1 and Fragile X Syndrome*","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"National Cancer Institute","keywords":"Nucleosome; Trinucleotide repeat expansion; Biology; Histone; Genetics; DNA methylation; Spinocerebellar ataxia; Methylation; CpG site; DNA; Transcription (linguistics); Molecular biology; Gene; Allele; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002090917,0.0001607402,0.0002465674,0.00003062683,0.00004585976,0.00001337876,0.0001087893,0.0001838174,0.0000227866],"category_scores_gemma":[0.0003214124,0.0001065827,0.00006839422,0.00007902572,0.00007531505,0.000003772848,0.00007364662,0.0001375384,0.000001591279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001957401,"about_ca_system_score_gemma":0.00003720075,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001835308,"about_ca_topic_score_gemma":8.512483e-7,"domain_scores_codex":[0.9991826,0.00004884269,0.0002984412,0.0002263243,0.0001122868,0.0001315295],"domain_scores_gemma":[0.9994391,0.0000465624,0.0002188215,0.000128869,0.00006595565,0.0001007398],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008571289,0.00009059443,0.0008167166,0.0000550613,0.00004636603,0.00002521667,0.00001224224,0.00009162045,0.996149,0.000003579109,0.00005313448,0.00179931],"study_design_scores_gemma":[0.001177607,0.006463871,0.01813577,0.00009876907,0.00002598717,0.0002428257,0.0000276469,0.000005823472,0.9730067,0.00005526856,0.0006184411,0.0001413368],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992151,0.0003321907,0.00002054384,0.0001041197,0.00005913246,0.00008191467,0.00001237139,0.000003483957,0.0001711972],"genre_scores_gemma":[0.9984369,0.001135576,0.0002308775,0.00008496911,0.00002647695,0.000001971145,0.00002259344,0.00001060507,0.00005008978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02314238,"threshold_uncertainty_score":0.4346317,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01723994576206209,"score_gpt":0.273402335339002,"score_spread":0.2561623895769399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}