{"id":"W2153455336","doi":"10.1074/jbc.m413239200","title":"Effect of CAT or AGG Interruptions and CpG Methylation on Nucleosome Assembly upon Trinucleotide Repeats on Spinocerebellar Ataxia, Type 1 and Fragile X Syndrome*","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"National Cancer Institute","keywords":"Nucleosome; Trinucleotide repeat expansion; Biology; Histone; Genetics; DNA methylation; Spinocerebellar ataxia; Methylation; CpG site; DNA; Transcription (linguistics); Molecular biology; Gene; Allele; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001859913,0.0002727307,0.0002697588,0.0001358779,0.00009540381,0.0001236254,0.0001945499,0.0002186349,0.001004145],"category_scores_gemma":[0.0002919813,0.000157698,0.0001804031,0.0001014827,0.0002131018,0.00007897626,0.0002032866,0.0003143214,0.0001363168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001560261,"about_ca_system_score_gemma":0.0001310723,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002117623,"about_ca_topic_score_gemma":0.003661859,"domain_scores_codex":[0.9998454,0.0000466897,0.00001754022,0.00002827248,0.00003260501,0.00002947655],"domain_scores_gemma":[0.999703,0.000118617,0.00005963598,0.00002383509,0.00001795917,0.00007693945],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000814031,0.00004214001,0.0008819343,0.00003855157,0.00002077953,0.00009987783,0.00003707776,0.00008403799,0.9964791,0.00002881781,0.00002045011,0.001453168],"study_design_scores_gemma":[0.00006805682,0.002725417,0.03617822,0.00001355063,0.0001029961,0.0004812294,0.00004966751,0.001116495,0.9571711,0.00003968474,0.002039789,0.00001391358],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985666,0.0007611374,0.0002031236,0.00002119008,0.000009163215,0.000007402503,0.00008030841,0.0000125313,0.0003385129],"genre_scores_gemma":[0.9983241,0.000352307,0.0005076424,0.00003248981,0.000008080459,0.00001109624,0.0002050851,0.00001122355,0.0005478699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002117623,"threshold_uncertainty_score":0.004210591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01723994576206209,"score_gpt":0.273402335339002,"score_spread":0.2561623895769399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}