{"id":"W2153459584","doi":"10.1093/intimm/dxp098","title":"Expression of fully assembled TCR-CD3 complex on double positive thymocytes: synergistic role for the PRS and ER retention motifs in the intra-cytoplasmic tail of CD3 ","year":2009,"lang":"en","type":"article","venue":"International Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research","keywords":"T-cell receptor; Thymocyte; Biology; CD3; CD8; Cell biology; Double negative; Cytoplasm; Endoplasmic reticulum; Transgene; Molecular biology; ER retention; T cell; Gene; Genetics; Antigen; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009456798,0.0002770741,0.0001410487,0.000119111,0.0001001333,0.000251291,0.0001214733,0.0001387216,0.000870241],"category_scores_gemma":[0.00008692774,0.0001227248,0.0001496622,0.00007166134,0.0001115277,0.0001394909,0.0002075205,0.0004205508,0.0003011442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002300075,"about_ca_system_score_gemma":0.0001186102,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001797171,"about_ca_topic_score_gemma":0.0003501626,"domain_scores_codex":[0.9998714,0.00001750686,0.00001100044,0.00002405985,0.00003562031,0.00004037942],"domain_scores_gemma":[0.9998895,0.00001430857,0.00002793682,0.00001490461,0.00001357229,0.00003981869],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001415307,0.000002002929,0.0000365621,0.000003883089,5.602033e-7,0.00001718259,0.000001935548,0.00000567594,0.9998122,0.00001281594,0.000002644234,0.00009033591],"study_design_scores_gemma":[0.000007391275,0.00008868943,0.00400128,0.000003054477,0.000008962544,0.000391454,0.00001484956,0.0004731711,0.9944253,0.0000215472,0.0005621884,0.000002055564],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997274,0.0002605612,0.001759,0.00001979211,0.000005883222,0.000005660791,0.00007660903,0.00002603346,0.0005726004],"genre_scores_gemma":[0.9963653,0.0001641774,0.001672041,0.00002379878,0.000004196346,0.000008233758,0.0003240348,0.00002288532,0.001415355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000870241,"threshold_uncertainty_score":0.00291121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01940034783649442,"score_gpt":0.2641372141568723,"score_spread":0.2447368663203779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}