{"id":"W2153483615","doi":"10.2174/0929867024606704","title":"Thiol-Dependent Enzymes and Their Inhibitors: A Review","year":2002,"lang":"en","type":"review","venue":"Current Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"Apotex (Canada)","funders":"","keywords":"Proteases; Cysteine protease; Cysteine; Cathepsin; Thiol; Chemistry; Enzyme; Cysteine Proteinase Inhibitors; Biochemistry; Protease; Peptidomimetic; Rhinovirus; Pharmacology; Caspase; Medicine; Immunology; Programmed cell death; Virus; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004019299,0.0009350656,0.002738786,0.00002406109,0.0001005377,0.00003666087,0.0005514204,0.0006350984,0.005393871],"category_scores_gemma":[0.0006535084,0.0005243661,0.000675923,0.0001427275,0.0002399323,0.00004395071,0.0003015359,0.001504628,0.00005714248],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000174728,"about_ca_system_score_gemma":0.0001165081,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002582977,"about_ca_topic_score_gemma":1.350946e-7,"domain_scores_codex":[0.9971294,0.00007080896,0.0009227872,0.0009827698,0.000402508,0.0004916745],"domain_scores_gemma":[0.9977722,0.0005061244,0.0006580392,0.0006476611,0.00005793622,0.0003580144],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000001653935,0.0001294637,0.000003518781,0.1951871,0.00007324226,0.00001142149,0.000007082209,5.066269e-10,0.0001083049,0.000001239741,0.004407155,0.8000699],"study_design_scores_gemma":[0.000100505,0.000008639656,1.235043e-7,0.1798992,0.0005742993,0.0002382099,0.00001564481,6.64892e-7,0.001565629,0.00001128311,0.8171024,0.0004833752],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00002272161,0.9914394,0.000001204964,0.0000728981,0.0001973037,0.0002141414,0.0002071868,0.000115033,0.007730084],"genre_scores_gemma":[0.00007666826,0.9967292,0.000003490802,0.00004180114,0.002042854,0.0001762703,0.000266792,0.00004510491,0.0006178438],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8126953,"threshold_uncertainty_score":0.9997208,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08353658814692388,"score_gpt":0.3249277320088695,"score_spread":0.2413911438619456,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}