{"id":"W2153503204","doi":"10.3389/fnmol.2012.00038","title":"Structural basis for the regulation of L-type voltage-gated calcium channels: interactions between the N-terminal cytoplasmic domain and Ca2+-calmodulin","year":2012,"lang":"en","type":"article","venue":"Frontiers in Molecular Neuroscience","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Fondation pour la Recherche Médicale","keywords":"Calmodulin; Cytoplasm; Calcium; Chemistry; Peptide; Biophysics; Voltage-dependent calcium channel; EF hand; Calcium channel; C-terminus; Biochemistry; Amino acid; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003022654,0.0001104097,0.0001029364,0.00006603413,0.0001890192,0.00002591105,0.0001723917,0.00006553514,0.000002563376],"category_scores_gemma":[0.0001793975,0.0000759334,0.00004536529,0.0002289619,0.0002482763,0.00002060682,0.00006444647,0.00009033128,2.617789e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001701071,"about_ca_system_score_gemma":0.00002574044,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001014627,"about_ca_topic_score_gemma":0.000001638881,"domain_scores_codex":[0.9991472,0.00008367377,0.000188638,0.0002231269,0.0001397727,0.0002175954],"domain_scores_gemma":[0.9995414,0.0000329566,0.0001031091,0.0002156946,0.00005815677,0.00004868929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001782343,0.00002530796,0.02114696,0.0000209114,0.00001794553,8.615353e-7,0.0003196649,0.005549204,0.9659747,0.0001881742,0.00195585,0.004622158],"study_design_scores_gemma":[0.001359946,0.0005535703,0.2411628,0.00004089627,0.0001178979,0.0001480315,0.001003382,0.1994839,0.4990996,0.0008567746,0.05559136,0.0005817818],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7492649,0.0002143561,0.2476867,0.0002575304,0.002237334,0.0003033933,0.00001641027,0.000004941512,0.00001449991],"genre_scores_gemma":[0.9984518,0.00001670992,0.0009464602,0.0001864617,0.0002107986,0.00001560606,0.00003385279,0.0000112041,0.0001270652],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4668751,"threshold_uncertainty_score":0.3096474,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02233535302454629,"score_gpt":0.2721387860531593,"score_spread":0.249803433028613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}