{"id":"W2153554955","doi":"10.1126/science.1072105","title":"The Calicheamicin Gene Cluster and Its Iterative Type I Enediyne PKS","year":2002,"lang":"en","type":"article","venue":"Science","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":291,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"National Institute of General Medical Sciences; National Cancer Institute","keywords":"Enediyne; Calicheamicin; Gene cluster; Locus (genetics); Biology; Gene; Genetics; Polyketide synthase; Biosynthesis; Chemistry; Stereochemistry; Polyketide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003242672,0.00005910435,0.00007212952,0.00003164832,0.0002881882,0.00005113228,0.000101312,0.00002374117,0.00007403068],"category_scores_gemma":[0.0003814645,0.00002922307,0.00001121464,0.0003438977,0.0002913078,0.00009217312,0.00005626765,0.00008524526,0.00005611285],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002162112,"about_ca_system_score_gemma":0.00002253104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004623994,"about_ca_topic_score_gemma":0.000004697613,"domain_scores_codex":[0.9993568,0.0000142255,0.00007927304,0.0002095813,0.0001575952,0.0001825303],"domain_scores_gemma":[0.9995894,0.00003931395,0.00002232211,0.0001406023,0.0001363021,0.00007203394],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001817338,0.00001235444,0.00007629012,0.000005157029,0.000003225471,0.000002826507,0.000310908,2.144909e-7,0.9867728,0.0001185878,0.001907509,0.01077192],"study_design_scores_gemma":[0.0002349179,0.0001655722,0.003298501,0.0000292752,0.00001613607,0.00008911463,0.00004692474,0.0022189,0.9423441,0.00004128433,0.05141886,0.00009636019],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9786524,0.004028412,0.000002211316,0.01552301,0.0002538298,0.0001703743,0.000002109659,0.00001381924,0.001353861],"genre_scores_gemma":[0.9906787,0.0004186496,0.0001588504,0.001541732,0.0001339655,2.08313e-7,2.981842e-7,0.000002964962,0.007064688],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04951135,"threshold_uncertainty_score":0.221654,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02247760380849466,"score_gpt":0.2612591790025519,"score_spread":0.2387815751940572,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}