{"id":"W2153554955","doi":"10.1126/science.1072105","title":"The Calicheamicin Gene Cluster and Its Iterative Type I Enediyne PKS","year":2002,"lang":"en","type":"article","venue":"Science","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":291,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"National Institute of General Medical Sciences; National Cancer Institute","keywords":"Enediyne; Calicheamicin; Gene cluster; Locus (genetics); Biology; Gene; Genetics; Polyketide synthase; Biosynthesis; Chemistry; Stereochemistry; Polyketide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007806583,0.0002241414,0.0001714783,0.0001684912,0.0001885871,0.0003748101,0.0001848517,0.0002838699,0.0008532937],"category_scores_gemma":[0.0002919025,0.0001047635,0.0001632541,0.0001989846,0.0002607703,0.0002847443,0.0003336949,0.0004388594,0.0003373077],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004948564,"about_ca_system_score_gemma":0.0004106768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009299004,"about_ca_topic_score_gemma":0.001016058,"domain_scores_codex":[0.9999001,0.000007539909,0.000004534764,0.00003309966,0.00003483434,0.00001992406],"domain_scores_gemma":[0.9998286,0.00003629678,0.00004015546,0.00002829078,0.00002446787,0.00004219947],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009391894,0.00001933086,0.002091032,0.00002482041,0.000003628989,0.0002828775,0.00005755057,0.0002532708,0.988123,0.001214828,0.00004011188,0.007795634],"study_design_scores_gemma":[0.00003419629,0.0004038817,0.04901154,0.00002114206,0.00002653933,0.003893254,0.000139329,0.003199542,0.92595,0.002140729,0.01515592,0.0000239157],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873698,0.0005806863,0.008440638,0.0001382238,0.00001228004,0.00002259994,0.0003030739,0.0000790773,0.003053634],"genre_scores_gemma":[0.9812253,0.0004480988,0.01241054,0.00007809591,0.000009700002,0.00001724116,0.001412101,0.00001806455,0.004380906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009299004,"threshold_uncertainty_score":0.003590405,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02247760380849466,"score_gpt":0.2612591790025519,"score_spread":0.2387815751940572,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}