{"id":"W2153563181","doi":"10.1095/biolreprod.110.085480","title":"Side-by-Side Comparison of Five Commercial Media Systems in a Mouse Model: Suboptimal In Vitro Culture Interferes with Imprint Maintenance1","year":2010,"lang":"en","type":"article","venue":"Biology of Reproduction","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":208,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Western University","funders":"Institute of Gender and Health; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; March of Dimes Foundation","keywords":"Genomic imprinting; Biology; Embryo culture; Imprinting (psychology); Blastocyst; Embryo; Epigenetics; DNA methylation; Andrology; Genetics; In vivo; Reproductive technology; Embryogenesis; Cell biology; Gene expression; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00159747,0.001016219,0.001179135,0.001533439,0.0004432493,0.0007996419,0.0006353265,0.001034378,0.001490088],"category_scores_gemma":[0.001097631,0.0003909291,0.001087608,0.0004892449,0.0006818603,0.0005939612,0.0007175861,0.001446218,0.000421553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005293409,"about_ca_system_score_gemma":0.0003855299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001253443,"about_ca_topic_score_gemma":0.002327924,"domain_scores_codex":[0.9981871,0.0004560783,0.0003096035,0.0003637873,0.0005095978,0.0001737059],"domain_scores_gemma":[0.9978672,0.0006997979,0.0005320981,0.000338601,0.0002702244,0.000291943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004231548,0.001129677,0.001791883,0.0002033335,0.000100481,0.0001766248,0.00007894053,0.0003309364,0.987688,0.0001066541,0.0001344335,0.004027604],"study_design_scores_gemma":[0.00009893601,0.01508467,0.007084982,0.00002198092,0.0003220219,0.0003019697,0.00009083867,0.001281993,0.9734079,0.00007591448,0.002189732,0.00003911501],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914561,0.002645243,0.003310293,0.00008805989,0.0001470061,0.0002454256,0.001031155,0.0000751297,0.001001525],"genre_scores_gemma":[0.968029,0.004160132,0.01678037,0.0002674047,0.000102955,0.0009577026,0.003977045,0.0002144739,0.005510987],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00159747,"threshold_uncertainty_score":0.008448303,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01211776823112185,"score_gpt":0.2601739981159074,"score_spread":0.2480562298847856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}