{"id":"W2153624732","doi":"10.1084/jem.192.3.325","title":"Deficiency in the Transcription Factor Interferon Regulatory Factor (Irf)-2 Leads to Severely Compromised Development of Natural Killer and T Helper Type 1 Cells","year":2000,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":173,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amgen (Canada); University of Toronto; Ontario Institute for Cancer Research","funders":"National Cancer Institute; Medical Research Council; National Institutes of Health; Medical Research Council Canada; Deutsche Forschungsgemeinschaft","keywords":"Interferon regulatory factors; IRF1; Biology; Interferon; Transcription factor; IRF4; Immunology; Cell biology; Innate immune system; Immune system; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002171575,0.001227139,0.0003751193,0.0005662169,0.0001530011,0.0003323446,0.0003182134,0.0005531025,0.002740505],"category_scores_gemma":[0.0002710466,0.0004158385,0.0002479186,0.0002230958,0.0005374257,0.0002556796,0.0003685984,0.0005450542,0.0009632972],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002265672,"about_ca_system_score_gemma":0.0001738973,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00020953,"about_ca_topic_score_gemma":0.0003419267,"domain_scores_codex":[0.9996876,0.00007190418,0.00004319856,0.00008466422,0.00006503625,0.00004771423],"domain_scores_gemma":[0.9996004,0.00007249043,0.0001529827,0.00004750879,0.00001570214,0.0001109627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003104942,0.00006667955,0.0003242973,0.00004468643,0.00001207468,0.0003141309,0.00001424269,0.0001495524,0.9970497,0.0002055376,0.00008461744,0.001423949],"study_design_scores_gemma":[0.000262462,0.001473472,0.01822007,0.000056802,0.0001120438,0.008331385,0.00008601034,0.002515334,0.9607474,0.0005942195,0.007562907,0.00003786002],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909776,0.001393836,0.00397517,0.00009536537,0.0000450055,0.00004044452,0.001029719,0.0003040343,0.002138869],"genre_scores_gemma":[0.9900736,0.000926127,0.003557995,0.00007303491,0.00001967257,0.00004189321,0.001242113,0.00009449697,0.003971082],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002740505,"threshold_uncertainty_score":0.00916791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02216437964162851,"score_gpt":0.2646595367930001,"score_spread":0.2424951571513716,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}