{"id":"W215368981","doi":"10.1023/a:1025542424986","title":"Oxidative stress and activation of proteasome protease during serum deprivation-induced apoptosis in rat hepatoma cells; inhibition of cell death by melatonin","year":2003,"lang":"en","type":"article","venue":"APOPTOSIS","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Windsor","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Apoptosis; Oxidative stress; Melatonin; Programmed cell death; Reactive oxygen species; Glutathione; Endocrinology; Internal medicine; Cell biology; Biology; Chemistry; Medicine; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002225763,0.0005331673,0.000397598,0.0003833663,0.0002766795,0.0002928413,0.0002523373,0.0002999713,0.0009354376],"category_scores_gemma":[0.0001380111,0.0002570925,0.0004539733,0.0004112449,0.0004200105,0.0004305341,0.000158537,0.0006559488,0.0001959071],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005250481,"about_ca_system_score_gemma":0.0004021757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001788624,"about_ca_topic_score_gemma":0.003365733,"domain_scores_codex":[0.9998507,0.00002556418,0.00002089008,0.00001898743,0.0000271381,0.00005660972],"domain_scores_gemma":[0.9998729,0.00002093562,0.00003605788,0.00002134914,0.00001771808,0.0000309265],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002277556,0.00006711819,0.0005263271,0.00007445073,0.00001538169,0.0002184792,0.00004897391,0.00006093914,0.9951786,0.0002054767,0.00004509705,0.001281598],"study_design_scores_gemma":[0.00005328498,0.0007468537,0.006073535,0.000003843641,0.00002861056,0.0001801379,0.00004035702,0.000313126,0.9918557,0.00007362512,0.0006255978,0.000005266647],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928196,0.004051922,0.00147687,0.0001385025,0.00007286226,0.0000292895,0.0003821221,0.00008817973,0.0009405927],"genre_scores_gemma":[0.9966737,0.001025779,0.0006360951,0.00003077896,0.0000194126,0.0000279161,0.0002949567,0.000006509517,0.001284988],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001788624,"threshold_uncertainty_score":0.003809452,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007408801939980021,"score_gpt":0.2109507385086871,"score_spread":0.2035419365687071,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}