{"id":"W2153696453","doi":"10.1073/pnas.0711232105","title":"Carboxypeptidase E mediates palmitate-induced β-cell ER stress and apoptosis","year":2008,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":149,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Center for Research Resources; National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research; National Institutes of Health; Michael Smith Health Research BC; Canadian Diabetes Association","keywords":"Unfolded protein response; Apoptosis; Programmed cell death; Beta cell; Endoplasmic reticulum; Proinsulin; Cell biology; Carboxypeptidase; Lipotoxicity; Biology; Internal medicine; Endocrinology; Chemistry; Insulin; Islet; Biochemistry; Insulin resistance; Medicine; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003591695,0.0000780658,0.000170542,0.0001298601,0.0001377287,0.000006703862,0.0001563962,0.00006139698,0.00002033644],"category_scores_gemma":[0.000620621,0.00004753088,0.0000481026,0.0004066911,0.0006115153,0.0001731627,0.00005271267,0.0001053456,0.000001567413],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001447278,"about_ca_system_score_gemma":0.0000387608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008569435,"about_ca_topic_score_gemma":1.219963e-8,"domain_scores_codex":[0.9987282,0.000003468386,0.0002087366,0.0001702296,0.0007723215,0.0001170564],"domain_scores_gemma":[0.9993816,0.0001422641,0.0001883257,0.000006212214,0.0002162288,0.00006537459],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002320037,0.00008361186,0.1821879,0.0001487519,0.00001765236,1.106175e-8,0.0003530612,0.000002332151,0.8145237,0.001688988,0.0008790616,0.00009176393],"study_design_scores_gemma":[0.0004050802,0.00008244129,0.18217,0.00009874186,0.0000252409,0.000007505293,0.0003038155,0.0001988971,0.8153134,0.00130335,0.00003978458,0.00005169397],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9800301,0.0001674603,4.770408e-8,0.001742997,0.00001564546,0.00012036,0.000007575701,0.0000112734,0.01790456],"genre_scores_gemma":[0.998634,0.0000922685,0.0005109078,0.000367496,0.00006052297,0.000006917856,1.745546e-7,0.000003189007,0.0003244613],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01860398,"threshold_uncertainty_score":0.2253153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0481766874022422,"score_gpt":0.2863954627495828,"score_spread":0.2382187753473406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}