{"id":"W2153696453","doi":"10.1073/pnas.0711232105","title":"Carboxypeptidase E mediates palmitate-induced β-cell ER stress and apoptosis","year":2008,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":149,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Center for Research Resources; National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research; National Institutes of Health; Michael Smith Health Research BC; Canadian Diabetes Association","keywords":"Unfolded protein response; Apoptosis; Programmed cell death; Beta cell; Endoplasmic reticulum; Proinsulin; Cell biology; Carboxypeptidase; Lipotoxicity; Biology; Internal medicine; Endocrinology; Chemistry; Insulin; Islet; Biochemistry; Insulin resistance; Medicine; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002117801,0.0003562409,0.0003303646,0.0002149324,0.0001549375,0.0003327936,0.0001431854,0.0002545755,0.001033192],"category_scores_gemma":[0.0001823339,0.0001420869,0.0002780429,0.0001516854,0.0001948375,0.0002902654,0.0003089787,0.0004778662,0.0005335542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002603356,"about_ca_system_score_gemma":0.0001619363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000221062,"about_ca_topic_score_gemma":0.0002794634,"domain_scores_codex":[0.9998884,0.00001928467,0.00001181174,0.00002226455,0.00002737904,0.00003077997],"domain_scores_gemma":[0.9999081,0.00001534312,0.00002609391,0.00001303548,0.00001606997,0.00002133996],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004027248,0.00004164119,0.000861697,0.0000665288,0.00001876389,0.0001942032,0.00001405951,0.00005299976,0.9952633,0.00009253043,0.00008298496,0.002908503],"study_design_scores_gemma":[0.00005817148,0.0001930792,0.01690037,0.00001382697,0.00002363111,0.001233244,0.00004723606,0.0007190563,0.9780915,0.0002060015,0.002508493,0.000005313651],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869466,0.006823088,0.003965051,0.0002958681,0.00004131134,0.00002930469,0.0003229358,0.00005122614,0.001524672],"genre_scores_gemma":[0.9898732,0.004796869,0.001963408,0.0001562433,0.00001992955,0.00003127376,0.0007018089,0.0000145102,0.00244281],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001033192,"threshold_uncertainty_score":0.003456354,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0481766874022422,"score_gpt":0.2863954627495828,"score_spread":0.2382187753473406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}