{"id":"W2153702353","doi":"10.1093/protein/14.6.427","title":"Antifibrinolytic effect of single apo(a) kringle domains: relationship to fibrinogen binding","year":2001,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Blood properties and coagulation","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Plasmin; Fibrin; Fibrinolysis; Fibrinogen; Kringle domain; Chemistry; Lysine; Lysis; Biochemistry; Binding site; Mutant; Plasma protein binding; Lipoprotein(a); Apolipoprotein B; Immunology; Biology; Amino acid; Medicine; Internal medicine; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000250022,0.0001192904,0.0001891097,0.0001996191,0.00006600469,0.00002100263,0.00002370056,0.00007393509,0.000008696276],"category_scores_gemma":[0.0001385365,0.0001077629,0.00003599024,0.0003855958,0.000008868475,0.00008629163,0.00001302177,0.00008998236,0.000006053288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005429977,"about_ca_system_score_gemma":0.00001297104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001910088,"about_ca_topic_score_gemma":5.056522e-7,"domain_scores_codex":[0.9993089,0.00003704583,0.0001759639,0.0001753899,0.0001288274,0.0001738183],"domain_scores_gemma":[0.9997066,0.00005900429,0.00003757258,0.00007885114,0.00003991484,0.00007802544],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002675654,0.00002463815,0.01109615,0.0002128696,0.00002954023,0.000002355425,0.0000687949,0.007399373,0.9756386,0.0000683865,0.000009884777,0.005181791],"study_design_scores_gemma":[0.0006812775,0.002144436,0.01759575,0.0003804271,0.00008324593,0.000127137,0.000005450183,0.03580971,0.9426364,0.00001862856,0.0003530785,0.0001644578],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8807404,0.000160661,0.1179493,0.000069304,0.00003241717,0.000860111,3.112203e-7,0.0001128491,0.00007465658],"genre_scores_gemma":[0.9908512,0.000006096662,0.008638534,0.00000627251,0.00007652389,0.00006052736,0.000003428207,0.00002446936,0.0003328957],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1101108,"threshold_uncertainty_score":0.4394445,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02109860247101522,"score_gpt":0.2242075478263887,"score_spread":0.2031089453553734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}