{"id":"W2153702353","doi":"10.1093/protein/14.6.427","title":"Antifibrinolytic effect of single apo(a) kringle domains: relationship to fibrinogen binding","year":2001,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Blood properties and coagulation","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Plasmin; Fibrin; Fibrinolysis; Fibrinogen; Kringle domain; Chemistry; Lysine; Lysis; Biochemistry; Binding site; Mutant; Plasma protein binding; Lipoprotein(a); Apolipoprotein B; Immunology; Biology; Amino acid; Medicine; Internal medicine; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000150858,0.0002383103,0.0002537576,0.0001458587,0.00007764983,0.0003094925,0.000212167,0.0003162831,0.000530121],"category_scores_gemma":[0.000259664,0.0001110589,0.0002153482,0.00008546036,0.0001879119,0.0001479221,0.0001119883,0.0003526989,0.0001651426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002164136,"about_ca_system_score_gemma":0.0001001614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004951556,"about_ca_topic_score_gemma":0.0005261803,"domain_scores_codex":[0.9998646,0.00002609556,0.00001445282,0.00002213158,0.00003429997,0.00003842287],"domain_scores_gemma":[0.9997138,0.00008830059,0.00009190192,0.00002572099,0.00002882167,0.00005136494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001404428,0.00003099415,0.0002507333,0.00001822228,0.000006273928,0.00003196322,0.000006074095,0.00006345731,0.9986362,0.00001465182,0.00001010544,0.0007908345],"study_design_scores_gemma":[0.00001122525,0.0005780853,0.00574662,0.000002975433,0.00001151617,0.0002665775,0.00001249833,0.0005641278,0.992386,0.00001244781,0.0004027825,0.000005227568],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981432,0.001055081,0.0004479287,0.00002406842,0.000005033106,0.000006223739,0.00005330241,0.00001273053,0.0002525279],"genre_scores_gemma":[0.9983947,0.0003827002,0.000733537,0.00003073297,0.000004217065,0.000006463044,0.0001054041,0.0000054344,0.0003368412],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000530121,"threshold_uncertainty_score":0.001773417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02109860247101522,"score_gpt":0.2242075478263887,"score_spread":0.2031089453553734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}