{"id":"W2153702855","doi":"10.1093/infdis/jir769","title":"GLA-SE, a Synthetic Toll-like Receptor 4 Agonist, Enhances T-Cell Responses to Influenza Vaccine in Older Adults","year":2011,"lang":"en","type":"article","venue":"The Journal of Infectious Diseases","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":128,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Vancouver Coastal Health Research Institute; Vancouver Coastal Health","funders":"National Institute on Aging; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Immunology; Adjuvant; Peripheral blood mononuclear cell; Dendritic cell; Influenza vaccine; Toll-like receptor; ELISPOT; Cytokine; Vaccination; Medicine; Virology; Immune system; Biology; T cell; Innate immune system; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001840685,0.0002366822,0.0002606719,0.0001375892,0.00005698002,0.000098026,0.00008038986,0.0001733131,0.001038987],"category_scores_gemma":[0.0002600354,0.00006101298,0.0001515901,0.00005593046,0.00008576929,0.00009669016,0.0001444943,0.0002350374,0.0002333028],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004888202,"about_ca_system_score_gemma":0.0000905014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001229886,"about_ca_topic_score_gemma":0.0002262941,"domain_scores_codex":[0.9999603,0.00001280089,0.000004243672,0.000006187528,0.000006443823,0.00000993384],"domain_scores_gemma":[0.9999081,0.00001903902,0.00002130056,0.000004834641,0.00001282306,0.00003381514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.004190363,0.001098745,0.007399765,0.0001973011,0.00004367885,0.0001646308,0.00008970014,0.00009207644,0.9567382,0.00002055677,0.0002062479,0.02975878],"study_design_scores_gemma":[0.002278123,0.1349183,0.234735,0.0001168816,0.0004953395,0.002526948,0.0003119117,0.001738073,0.6155868,0.0001597352,0.00711401,0.00001876481],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987765,0.0007113859,0.0001846616,0.0000377429,0.00001297227,0.00001505632,0.00002536339,0.000009299126,0.000227056],"genre_scores_gemma":[0.9975937,0.0006570725,0.0008793281,0.0001051725,0.00004097869,0.00002121837,0.0001093104,0.000003318374,0.0005898023],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001038987,"threshold_uncertainty_score":0.003475785,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03488086446229681,"score_gpt":0.3300980795855936,"score_spread":0.2952172151232968,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}