{"id":"W2153723509","doi":"10.1074/jbc.m002812200","title":"Presenilin 1 Regulates Pharmacologically Distinct γ-Secretase Activities","year":2000,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute on Aging","keywords":"Presenilin; Neuroscience; Amyloid precursor protein secretase; Biology; Computational biology; Cell biology; Chemistry; Medicine; Amyloid precursor protein; Alzheimer's disease; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001592672,0.0003667067,0.0002640689,0.0003679105,0.0001996863,0.0005609414,0.0001442113,0.0002519682,0.0006671927],"category_scores_gemma":[0.0002280427,0.0001776479,0.0001820884,0.0001371941,0.0003042876,0.0002648392,0.0002041298,0.000559409,0.0001848919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005488301,"about_ca_system_score_gemma":0.0001945987,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003462298,"about_ca_topic_score_gemma":0.0008126848,"domain_scores_codex":[0.9998308,0.00002396223,0.00001783407,0.00003770089,0.00004793718,0.00004165947],"domain_scores_gemma":[0.9998546,0.00003134573,0.00004624909,0.00001324139,0.00001954125,0.00003507487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008180438,0.00001765668,0.0002229607,0.00002443137,0.000004507285,0.00004442189,0.00001585738,0.00002898899,0.9981924,0.0001025924,0.00002559668,0.001238813],"study_design_scores_gemma":[0.00003284119,0.0003167043,0.0309534,0.000009967182,0.00003812978,0.0003793525,0.00008738021,0.000377381,0.9658486,0.0002131238,0.00173672,0.000006338367],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955354,0.002497131,0.0003880868,0.00008239624,0.00001344069,0.000010934,0.00008752643,0.00003090743,0.001354199],"genre_scores_gemma":[0.9961611,0.002155493,0.0004705798,0.00007850757,0.00001322192,0.00002255023,0.00013051,0.000008851917,0.0009591331],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006671927,"threshold_uncertainty_score":0.003982008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03779982055851728,"score_gpt":0.331149006635138,"score_spread":0.2933491860766207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}