{"id":"W2153725546","doi":"10.1158/0008-5472.can-13-3596","title":"Immunosuppressive Myeloid Cells Induced by Chemotherapy Attenuate Antitumor CD4+ T-Cell Responses through the PD-1–PD-L1 Axis","year":2014,"lang":"en","type":"article","venue":"Cancer Research","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institutes of Health; American Cancer Society","keywords":"Chemoimmunotherapy; Cyclophosphamide; Cancer research; Medicine; Myeloid-derived Suppressor Cell; Immune system; Immunotherapy; Immunology; Myeloid; Cancer; Chemotherapy; Pharmacology; Internal medicine; Suppressor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.001045569,0.0002538987,0.0003035649,0.0001363727,0.0009021445,0.00009989589,0.0006782439,0.0002834972,0.005689338],"category_scores_gemma":[0.000168463,0.0001818213,0.0001361515,0.0003689658,0.0005265261,0.0002412654,0.0001666694,0.001390265,0.002965848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001824057,"about_ca_system_score_gemma":0.0001880325,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002070613,"about_ca_topic_score_gemma":0.00002338241,"domain_scores_codex":[0.9966434,0.001520829,0.0003588218,0.0005182163,0.0001736829,0.0007851029],"domain_scores_gemma":[0.9979137,0.0007449553,0.000153456,0.0007665189,0.0003888164,0.0000325332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001406526,0.00009166473,0.00003690484,0.00001596562,0.00007865785,9.288082e-7,0.000901555,0.000002233349,0.7373971,0.00004955484,0.2580037,0.002015211],"study_design_scores_gemma":[0.0009393601,0.0002312088,0.000370206,0.00003008832,0.000007516481,0.000005073336,0.0005356336,0.000003041086,0.5521801,0.00003336075,0.4455395,0.0001249884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.974356,0.005773635,0.0001112617,0.004856705,0.003900067,0.0006533766,0.0000350171,0.00008640307,0.01022753],"genre_scores_gemma":[0.8908026,0.001994281,0.000008225937,0.001346031,0.0001516883,0.0002013965,0.00006984444,0.00004809124,0.1053779],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1875358,"threshold_uncertainty_score":0.9978105,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03998289898138229,"score_gpt":0.3433612938903187,"score_spread":0.3033783949089364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}