{"id":"W2153725546","doi":"10.1158/0008-5472.can-13-3596","title":"Immunosuppressive Myeloid Cells Induced by Chemotherapy Attenuate Antitumor CD4+ T-Cell Responses through the PD-1–PD-L1 Axis","year":2014,"lang":"en","type":"article","venue":"Cancer Research","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institutes of Health; American Cancer Society","keywords":"Chemoimmunotherapy; Cyclophosphamide; Cancer research; Medicine; Myeloid-derived Suppressor Cell; Immune system; Immunotherapy; Immunology; Myeloid; Cancer; Chemotherapy; Pharmacology; Internal medicine; Suppressor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001085706,0.0003278868,0.0003652587,0.0002024004,0.0001013771,0.0002500856,0.0001251962,0.000155014,0.00107263],"category_scores_gemma":[0.00008721867,0.0001184482,0.0001360437,0.00008830107,0.000182484,0.000160461,0.0001807944,0.0008045327,0.00024996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002344003,"about_ca_system_score_gemma":0.0002803459,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002701145,"about_ca_topic_score_gemma":0.0005990529,"domain_scores_codex":[0.9998875,0.00002586168,0.000009736294,0.00001686161,0.00002557085,0.00003444174],"domain_scores_gemma":[0.9999281,0.000009664106,0.00002817087,0.000007203581,0.000005355943,0.00002156128],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005171251,0.0001900484,0.0003815482,0.00006910694,0.000007069711,0.00003891368,0.00002352896,0.0002054398,0.9897963,0.0001623198,0.0001621207,0.008446425],"study_design_scores_gemma":[0.0002256896,0.004956795,0.007848456,0.00002020297,0.00005143342,0.0003029299,0.00003326941,0.002263217,0.9758778,0.0001232566,0.00828995,0.000007043936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934668,0.002950307,0.001762884,0.0001459846,0.0000419781,0.00006884725,0.0001613252,0.0001375333,0.001264399],"genre_scores_gemma":[0.9954194,0.001189982,0.001451235,0.00007719716,0.00002899726,0.00006924549,0.0002045579,0.00001069498,0.001548796],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00107263,"threshold_uncertainty_score":0.003588259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03998289898138229,"score_gpt":0.3433612938903187,"score_spread":0.3033783949089364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}