{"id":"W2153747061","doi":"10.1074/jbc.m100710200","title":"Early-onset Amyloid Deposition and Cognitive Deficits in Transgenic Mice Expressing a Double Mutant Form of Amyloid Precursor Protein 695","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":954,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"","keywords":"Presenilin; Amyloid precursor protein; Genetically modified mouse; Transgene; Amyloid (mycology); Alzheimer's disease; Mutant; Morris water navigation task; Chemistry; Senile plaques; Endocrinology; Molecular biology; Internal medicine; Biology; Biochemistry; Medicine; Pathology; Hippocampus; Disease; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001730329,0.0001432938,0.0003628353,0.00004956868,0.00003801744,0.00001479254,0.00006352083,0.0001565485,0.00006693337],"category_scores_gemma":[0.00008290962,0.00009522448,0.0001309397,0.0001360741,0.0001438306,0.00009290504,0.00002147125,0.0003028224,0.00000146845],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005592861,"about_ca_system_score_gemma":0.000128771,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001595418,"about_ca_topic_score_gemma":0.00000158616,"domain_scores_codex":[0.9988817,0.00003891937,0.0004134763,0.0001662623,0.0002418,0.00025785],"domain_scores_gemma":[0.9992206,0.00007922232,0.0002177471,0.00006475951,0.0001593309,0.0002583919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01302589,0.001261865,0.08580591,0.0002044914,0.0009279155,0.0006303945,0.0002006407,3.079152e-7,0.8957,6.78323e-7,0.000004009876,0.002237828],"study_design_scores_gemma":[0.006944897,0.001168451,0.06607753,0.001118117,0.0002449542,0.001068771,0.0002747239,0.00001130892,0.9228186,0.0001537202,0.000004958732,0.0001139513],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941685,0.004948153,0.0000390573,0.00007745265,0.000007013674,0.0003286344,0.00003334222,0.000006756956,0.000391077],"genre_scores_gemma":[0.999244,0.0003817808,0.0002395264,0.0000153422,0.00006083257,0.00001862043,0.00002131719,0.000007911828,0.00001060744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02711855,"threshold_uncertainty_score":0.3883142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03634828922003999,"score_gpt":0.3035955700246503,"score_spread":0.2672472808046102,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}