{"id":"W2153760325","doi":"10.1161/01.res.0000086964.07404.a5","title":"Beneficial Effects of Trimetazidine in Ex Vivo Working Ischemic Hearts Are Due to a Stimulation of Glucose Oxidation Secondary to Inhibition of Long-Chain 3-Ketoacyl Coenzyme A Thiolase","year":2003,"lang":"en","type":"letter","venue":"Circulation Research","topic":"Cardiovascular Function and Risk Factors","field":"Medicine","cited_by":210,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Trimetazidine; Thiolase; Beta oxidation; Chemistry; Fatty acid; Biochemistry; Coenzyme A; Ex vivo; Enzyme; Pharmacology; Biology; In vitro; Dehydrogenase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002145905,0.0003068597,0.001162838,0.002918014,0.00006441181,0.0000221503,0.00009610235,0.0007560885,0.0001762196],"category_scores_gemma":[0.00172711,0.0003194711,0.0004318708,0.002262638,0.00008330559,0.0001137157,0.00007408446,0.00134782,0.00001817571],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004452514,"about_ca_system_score_gemma":0.0004251105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004624932,"about_ca_topic_score_gemma":0.00010508,"domain_scores_codex":[0.9952766,0.0007348061,0.001072114,0.0006375738,0.001840483,0.000438424],"domain_scores_gemma":[0.996958,0.0006795491,0.000397098,0.0006826535,0.00111519,0.0001675222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002028334,0.0006218303,0.0462914,0.009265902,0.0005871449,0.000661363,0.001611765,0.01795712,0.7727531,0.0000195239,0.1362801,0.01192242],"study_design_scores_gemma":[0.006051265,0.0007250886,0.4073866,0.005900269,0.00031741,0.0000825342,0.0002025383,0.001222208,0.5690915,0.00005900817,0.008406016,0.0005555764],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9833688,0.0004629901,0.005450644,0.006819308,0.0003070016,0.003365794,0.00003288053,0.00002628062,0.000166303],"genre_scores_gemma":[0.9946544,0.00003764295,0.0002054646,0.00367329,0.0005456498,0.00008510648,0.0006197459,0.00007232646,0.0001064136],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3610952,"threshold_uncertainty_score":0.9999257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04092436391966775,"score_gpt":0.315019080419724,"score_spread":0.2740947165000563,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}