{"id":"W2153760325","doi":"10.1161/01.res.0000086964.07404.a5","title":"Beneficial Effects of Trimetazidine in Ex Vivo Working Ischemic Hearts Are Due to a Stimulation of Glucose Oxidation Secondary to Inhibition of Long-Chain 3-Ketoacyl Coenzyme A Thiolase","year":2003,"lang":"en","type":"letter","venue":"Circulation Research","topic":"Cardiovascular Function and Risk Factors","field":"Medicine","cited_by":210,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Trimetazidine; Thiolase; Beta oxidation; Chemistry; Fatty acid; Biochemistry; Coenzyme A; Ex vivo; Enzyme; Pharmacology; Biology; In vitro; Dehydrogenase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002912242,0.0005762517,0.0005179071,0.0002213073,0.0001399644,0.000285275,0.0003879648,0.000317431,0.002543692],"category_scores_gemma":[0.0002251989,0.0001948646,0.0002786227,0.0001529497,0.0003500447,0.0003463931,0.0001361294,0.000771798,0.000395981],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001413379,"about_ca_system_score_gemma":0.0001742881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000404765,"about_ca_topic_score_gemma":0.001001533,"domain_scores_codex":[0.9999217,0.00002356188,0.00001068937,0.00001261978,0.00001113352,0.00002030114],"domain_scores_gemma":[0.9997923,0.00006207648,0.00004431434,0.00002967722,0.0000219047,0.00004976298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004899818,0.0002448902,0.0002828211,0.0002574853,0.00003461199,0.0001359025,0.00003182314,0.0000427016,0.9848105,0.00005796859,0.0001601334,0.0090413],"study_design_scores_gemma":[0.00045145,0.007693814,0.004175481,0.00001106595,0.0000915981,0.000194807,0.00003230934,0.0002363454,0.9855914,0.00003352467,0.001482213,0.000005941557],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897696,0.005588742,0.001818598,0.0003101325,0.0002442343,0.00005137305,0.0002671157,0.0001590053,0.001791226],"genre_scores_gemma":[0.9899665,0.003771251,0.002438247,0.0001779648,0.000139898,0.00006040317,0.0003510921,0.00003367523,0.003061071],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002543692,"threshold_uncertainty_score":0.008509457,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04092436391966775,"score_gpt":0.315019080419724,"score_spread":0.2740947165000563,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}