{"id":"W2153778965","doi":"10.1002/jcph.570","title":"Pharmacokinetics and pharmacodynamics of a human monoclonal anti‐FGF23 antibody (KRN23) in the first multiple ascending‐dose trial treating adults with X‐linked hypophosphatemia","year":2015,"lang":"en","type":"article","venue":"The Journal of Clinical Pharmacology","topic":"Parathyroid Disorders and Treatments","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Shriners Hospitals for Children - Canada","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Kyowa Hakko Kirin; University of California, San Francisco; Shriners Hospitals for Children; Yale University","keywords":"Pharmacokinetics; Pharmacodynamics; Hypophosphatemia; Medicine; Pharmacology; Monoclonal antibody; Antibody; Internal medicine; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002969959,0.0002691965,0.001024581,0.0001380062,0.0001172365,0.00001283663,0.0003528544,0.0001364237,0.00001711022],"category_scores_gemma":[0.0003209642,0.0001370031,0.0001985456,0.0002930158,0.0004696327,0.0001145335,0.00007321904,0.0009564795,0.000002768855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004599594,"about_ca_system_score_gemma":0.000265205,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007699995,"about_ca_topic_score_gemma":0.00002610609,"domain_scores_codex":[0.9966432,0.0006548568,0.00166784,0.0002112075,0.0004810416,0.000341833],"domain_scores_gemma":[0.9961916,0.001792185,0.001294913,0.0001767339,0.000282589,0.0002620221],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3512925,0.009421346,0.6031581,0.00009553461,0.001846816,0.00124446,0.004629317,0.0009352021,0.01425559,0.00001733441,0.01018761,0.002916175],"study_design_scores_gemma":[0.7301775,0.02127841,0.2182968,0.0002128959,0.004192047,0.001047617,0.002044854,0.01813401,0.0021862,0.0001465161,0.001909296,0.0003738585],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937773,0.002533734,0.00002242228,0.001738671,0.0006653173,0.0009957791,0.00001269788,0.000009091902,0.0002449925],"genre_scores_gemma":[0.9957303,0.002313631,0.0002304131,0.0008923342,0.000759907,0.00001053202,0.00001070287,0.00002671578,0.00002543419],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3848614,"threshold_uncertainty_score":0.5586824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08344190394491893,"score_gpt":0.4537382079247536,"score_spread":0.3702963039798347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}