{"id":"W2153806861","doi":"10.1124/dmd.106.009787","title":"THE NOVEL UGT1A9 INTRONIC I399 POLYMORPHISM APPEARS AS A PREDICTOR OF 7-ETHYL-10-HYDROXYCAMPTOTHECIN GLUCURONIDATION LEVELS IN THE LIVER","year":2006,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre hospitalier de l'Université Laval","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Center for Research Resources; National Institute of Mental Health; National Institute of General Medical Sciences; National Institute on Drug Abuse; National Institute on Aging; Canadian Institutes of Health Research","keywords":"Glucuronidation; Chemistry; Glucuronosyltransferase; Linkage disequilibrium; Irinotecan; Genotype; Internal medicine; Stereochemistry; Biochemistry; Biology; Single-nucleotide polymorphism; Enzyme; Gene; Genetics; Microsome; Medicine; Cancer; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005021077,0.0001311356,0.000146822,0.00003938761,0.0001176657,0.00004466564,0.0001577373,0.0000778228,0.00001462519],"category_scores_gemma":[0.00001421164,0.00008459354,0.00007917771,0.00009304354,0.0001420401,0.00001069669,0.00004560278,0.00007480825,0.000003088404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009891722,"about_ca_system_score_gemma":0.00004649168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006152626,"about_ca_topic_score_gemma":0.0002125932,"domain_scores_codex":[0.9990748,0.0001148548,0.0002381608,0.0002126213,0.0001737744,0.0001858487],"domain_scores_gemma":[0.9995303,0.00003280914,0.0001226397,0.0002470792,0.0000422741,0.00002488507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007496522,0.0001843394,0.00003299831,0.00002156679,0.00005358894,0.000001017872,0.0006431356,0.00008789908,0.8684128,0.1196033,0.0002720653,0.009937597],"study_design_scores_gemma":[0.01854256,0.0003308446,0.04910447,0.0001138692,0.0004725336,0.00006703664,0.00100271,0.002240928,0.7778578,0.03024205,0.119243,0.0007821765],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9793755,0.01551194,0.003364394,0.0005986948,0.0001569271,0.0003983189,0.00007697102,0.000005854175,0.0005114137],"genre_scores_gemma":[0.9971176,0.001667536,0.00006605024,0.0002728232,0.0002713454,0.00005513294,0.0001293503,0.00001360948,0.0004064922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.118971,"threshold_uncertainty_score":0.3449624,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005853984884818835,"score_gpt":0.2190550351426169,"score_spread":0.2132010502577981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}