{"id":"W2153806861","doi":"10.1124/dmd.106.009787","title":"THE NOVEL UGT1A9 INTRONIC I399 POLYMORPHISM APPEARS AS A PREDICTOR OF 7-ETHYL-10-HYDROXYCAMPTOTHECIN GLUCURONIDATION LEVELS IN THE LIVER","year":2006,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre hospitalier de l'Université Laval","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Center for Research Resources; National Institute of Mental Health; National Institute of General Medical Sciences; National Institute on Drug Abuse; National Institute on Aging; Canadian Institutes of Health Research","keywords":"Glucuronidation; Chemistry; Glucuronosyltransferase; Linkage disequilibrium; Irinotecan; Genotype; Internal medicine; Stereochemistry; Biochemistry; Biology; Single-nucleotide polymorphism; Enzyme; Gene; Genetics; Microsome; Medicine; Cancer; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002252565,0.0003082837,0.0004414622,0.0004754136,0.0003184355,0.000436633,0.0001919147,0.0004973251,0.001885986],"category_scores_gemma":[0.000973214,0.0002609245,0.0003185099,0.0006776352,0.0002557347,0.0002281514,0.0001356598,0.0006708554,0.0003759156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002206815,"about_ca_system_score_gemma":0.0002234903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001746765,"about_ca_topic_score_gemma":0.001967906,"domain_scores_codex":[0.9998242,0.00005082067,0.00001776217,0.00004444832,0.00003829084,0.00002448903],"domain_scores_gemma":[0.9986315,0.0004122536,0.0005701613,0.00008979856,0.00007170749,0.0002246166],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002323766,0.00009263909,0.955828,0.00001533299,0.0001212614,0.0005828019,0.00004417471,0.0001759459,0.03728171,0.00006787095,0.0001202207,0.003346303],"study_design_scores_gemma":[0.00002734497,0.0003142703,0.9912279,0.000004298717,0.00008725108,0.002186575,0.0000386066,0.001075336,0.004675644,0.0001084525,0.0002483194,0.000006051523],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991247,0.0001668632,0.0001564506,0.00006565497,0.000005429201,0.00000193901,0.0001067965,0.000008022095,0.000364162],"genre_scores_gemma":[0.9995968,0.00004523445,0.00008345365,0.00001096776,0.000008968921,0.000001091046,0.00008675689,0.000005590556,0.0001611698],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001885986,"threshold_uncertainty_score":0.006309211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005853984884818835,"score_gpt":0.2190550351426169,"score_spread":0.2132010502577981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}