{"id":"W2153806937","doi":"10.1002/em.21957","title":"Modified in vivo comet assay detects the genotoxic potential of 14‐hydroxycodeinone, an α,β‐unsaturated ketone in oxycodone","year":2015,"lang":"en","type":"article","venue":"Environmental and Molecular Mutagenesis","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Purdue Pharma (Canada)","funders":"","keywords":"Comet assay; Genotoxicity; DNA damage; In vivo; DNA; Chemistry; Molecular biology; Biology; Biochemistry; Toxicity; Genetics; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003751665,0.0008713919,0.0004405853,0.0006546679,0.0001585948,0.0002037908,0.0002806075,0.0006255506,0.001535703],"category_scores_gemma":[0.0002781455,0.0002570177,0.0004747961,0.0003282611,0.000249243,0.0003073701,0.0001736787,0.0008480892,0.0002937549],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000182775,"about_ca_system_score_gemma":0.0001796364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005083935,"about_ca_topic_score_gemma":0.001069936,"domain_scores_codex":[0.9996518,0.000061837,0.00003842396,0.00008405428,0.0001244034,0.00003948007],"domain_scores_gemma":[0.9994659,0.00009257688,0.0001990304,0.00005410462,0.000122331,0.00006611725],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005358085,0.00003168632,0.0002705078,0.00004766293,0.00001019081,0.0000264135,0.00001457974,0.00001765759,0.9991025,0.00001107125,0.00001118465,0.0004029476],"study_design_scores_gemma":[0.000008017548,0.001287291,0.004554463,0.000006938133,0.00002721393,0.0001597314,0.0000196592,0.0002564809,0.9931109,0.00001985682,0.0005435311,0.000005904647],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9721714,0.003380609,0.02090588,0.0001157801,0.0001231692,0.0001960875,0.0008752437,0.0002286554,0.002003328],"genre_scores_gemma":[0.9642731,0.003248101,0.0230282,0.0001719927,0.00004246284,0.000224309,0.002148669,0.00002616783,0.006837054],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001535703,"threshold_uncertainty_score":0.005137503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008749426316741025,"score_gpt":0.219040206674437,"score_spread":0.210290780357696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}