{"id":"W2153825225","doi":"10.1038/nn.3514","title":"Interaction of FUS and HDAC1 regulates DNA damage response and repair in neurons","year":2013,"lang":"en","type":"article","venue":"Nature Neuroscience","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":437,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Institutes of Health; U.S. Department of Veterans Affairs; National Institute of Neurological Disorders and Stroke; Howard Hughes Medical Institute","keywords":"Frontotemporal lobar degeneration; DNA damage; Amyotrophic lateral sclerosis; Biology; DNA repair; Histone; Neurodegeneration; HDAC1; Mutation; Histone deacetylase; DNA; Cell biology; Frontotemporal dementia; Gene; Genetics; Medicine; Pathology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001953868,0.0002730534,0.0003239685,0.0003106105,0.0006335459,0.000721829,0.0004190419,0.0004250231,0.002547629],"category_scores_gemma":[0.0002332312,0.000275491,0.0005499479,0.0001917837,0.0004137835,0.0007409376,0.0005556271,0.0005503881,0.0007829812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001467551,"about_ca_system_score_gemma":0.000337658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002069344,"about_ca_topic_score_gemma":0.004900234,"domain_scores_codex":[0.9997051,0.00002389505,0.00001624622,0.00007531717,0.00007531107,0.0001040416],"domain_scores_gemma":[0.9998891,0.00001338578,0.00003120106,0.00001356697,0.00001943623,0.00003329654],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004136949,0.00002377113,0.001638625,0.0000547272,0.00003684878,0.0001009292,0.00003986762,0.0001587642,0.9928793,0.0006523565,0.000369842,0.003631358],"study_design_scores_gemma":[0.00003548186,0.000124043,0.05674938,0.00001701809,0.00004774857,0.0004339589,0.0002427401,0.00287464,0.9330023,0.0005811461,0.005875139,0.00001647048],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9833006,0.006999563,0.003838775,0.0005265994,0.0001095876,0.00001078227,0.000652245,0.0001640499,0.00439785],"genre_scores_gemma":[0.9950687,0.0007001833,0.0008125091,0.0000881903,0.00001523518,0.000008424744,0.0004498338,0.00003244009,0.002824541],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002547629,"threshold_uncertainty_score":0.01064789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01636358075082616,"score_gpt":0.3098590168703459,"score_spread":0.2934954361195197,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}