{"id":"W2153825225","doi":"10.1038/nn.3514","title":"Interaction of FUS and HDAC1 regulates DNA damage response and repair in neurons","year":2013,"lang":"en","type":"article","venue":"Nature Neuroscience","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":437,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Institutes of Health; U.S. Department of Veterans Affairs; National Institute of Neurological Disorders and Stroke; Howard Hughes Medical Institute","keywords":"Frontotemporal lobar degeneration; DNA damage; Amyotrophic lateral sclerosis; Biology; DNA repair; Histone; Neurodegeneration; HDAC1; Mutation; Histone deacetylase; DNA; Cell biology; Frontotemporal dementia; Gene; Genetics; Medicine; Pathology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003102289,0.00008907253,0.0001523777,0.0001899245,0.00004714498,0.00002401687,0.00008775513,0.0001134179,0.00002189808],"category_scores_gemma":[0.001571136,0.00006762173,0.00002268799,0.0004148484,0.0003339306,0.0003012481,0.0001325917,0.0005811615,0.000002147737],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002500993,"about_ca_system_score_gemma":0.00003809692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006834551,"about_ca_topic_score_gemma":0.000008667297,"domain_scores_codex":[0.9988427,0.000141526,0.0001657089,0.0003504641,0.0002934959,0.000206153],"domain_scores_gemma":[0.9993118,0.0002087092,0.00004791099,0.0002383571,0.00006909981,0.0001241202],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003133068,0.00004061502,0.02039167,0.00003029502,6.664944e-7,0.0000305334,0.0001013894,0.000002416058,0.9777938,0.00002688995,0.0004521735,0.0008162919],"study_design_scores_gemma":[0.0003882397,0.000391867,0.9813648,0.00006605553,0.000003254118,0.00007715547,0.00002185837,0.003379518,0.01352874,0.0000555585,0.0006711008,0.00005182287],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947658,0.0001082392,0.000001142921,0.004563047,0.000113816,0.0003089884,0.000002614054,0.00003079245,0.0001056261],"genre_scores_gemma":[0.9983766,0.00009971819,0.0001449486,0.0008856408,0.00001691775,0.000008297842,4.601148e-7,0.00000851576,0.0004588692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.964265,"threshold_uncertainty_score":0.2757534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01636358075082616,"score_gpt":0.3098590168703459,"score_spread":0.2934954361195197,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}