{"id":"W2153827414","doi":"10.1074/jbc.m110.134312","title":"Structural and Biochemical Studies on the Chromo-barrel Domain of Male Specific Lethal 3 (MSL3) Reveal a Binding Preference for Mono- or Dimethyllysine 20 on Histone H4","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; Saskatchewan Health Research Foundation; Canadian Institutes of Health Research; Massey University; University of Saskatchewan; Canadian Light Source","keywords":"Biology; Binding site; Histone; Biochemistry; Binding domain; In vitro; Mutation; Stereochemistry; Molecular biology; Chemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000423062,0.0002160002,0.0003653628,0.00002064591,0.00009526088,0.00001674739,0.0003219581,0.0002900722,0.00003807171],"category_scores_gemma":[0.0004725043,0.0001154637,0.000165193,0.00005528446,0.000394314,0.000002930284,0.0001202199,0.0003832775,4.858763e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002862026,"about_ca_system_score_gemma":0.00005129106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":4.232308e-7,"about_ca_topic_score_gemma":6.931343e-7,"domain_scores_codex":[0.9988574,0.00003431069,0.0004933024,0.000271904,0.0001347086,0.0002083719],"domain_scores_gemma":[0.9988457,0.0001835578,0.0004838251,0.0002441117,0.0001489289,0.00009386279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007473549,0.00006388334,0.0003500097,0.00005135667,0.00009804706,0.000006981053,0.00003546467,0.00001105041,0.9975078,0.00005833084,0.0008664122,0.0002033603],"study_design_scores_gemma":[0.000749916,0.0009995895,0.0005617785,0.00005510783,0.00002294338,0.0002721203,0.0002351383,0.00003757994,0.9955491,0.0005446943,0.0007943428,0.0001776322],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984788,0.0006436298,0.00003265918,0.0003540365,0.0001727595,0.000127712,0.00008491505,0.000002685927,0.0001027949],"genre_scores_gemma":[0.9958085,0.0002794316,0.003153666,0.00005121644,0.0004478349,0.000007270034,0.00003263037,0.00001224587,0.0002072418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003121007,"threshold_uncertainty_score":0.4708475,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04195692159294288,"score_gpt":0.2840949056849136,"score_spread":0.2421379840919707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}