{"id":"W2153827414","doi":"10.1074/jbc.m110.134312","title":"Structural and Biochemical Studies on the Chromo-barrel Domain of Male Specific Lethal 3 (MSL3) Reveal a Binding Preference for Mono- or Dimethyllysine 20 on Histone H4","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; Saskatchewan Health Research Foundation; Canadian Institutes of Health Research; Massey University; University of Saskatchewan; Canadian Light Source","keywords":"Biology; Binding site; Histone; Biochemistry; Binding domain; In vitro; Mutation; Stereochemistry; Molecular biology; Chemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001019035,0.0002799653,0.0001637121,0.0000658578,0.0001515236,0.0001514462,0.0001891398,0.0002654775,0.0006893687],"category_scores_gemma":[0.0001327445,0.0000989187,0.0002866886,0.00009155361,0.0001820089,0.000125392,0.0001428407,0.0004074865,0.0002482384],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000469141,"about_ca_system_score_gemma":0.0001662016,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002560884,"about_ca_topic_score_gemma":0.002700741,"domain_scores_codex":[0.9999552,0.000006842679,0.000002515836,0.000008825224,0.00001649597,0.00001018328],"domain_scores_gemma":[0.9999344,0.00001091724,0.00002276988,0.000002636685,0.000007556127,0.00002177048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001764686,0.0000199512,0.001739442,0.00003742656,0.000009769766,0.0001874207,0.00004445412,0.0003496533,0.9964972,0.00009535703,0.00004788144,0.0007949629],"study_design_scores_gemma":[0.00003018903,0.0002831779,0.04040438,0.000009788593,0.00003214494,0.001381406,0.0001467949,0.003779629,0.9510682,0.000104634,0.002739337,0.0000202259],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985955,0.0003864635,0.0005757842,0.000061471,0.000003973367,0.000003748303,0.0001550024,0.00001281023,0.0002052789],"genre_scores_gemma":[0.9974716,0.0002754427,0.001191268,0.00005781036,0.000003365522,0.000003201801,0.0005071211,0.000005663345,0.0004846661],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002560884,"threshold_uncertainty_score":0.005092025,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04195692159294288,"score_gpt":0.2840949056849136,"score_spread":0.2421379840919707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}