{"id":"W2153867928","doi":"10.1182/blood-2005-12-5115","title":"Multiyear therapeutic benefit of AAV serotypes 2, 6, and 8 delivering factor VIII to hemophilia A mice and dogs","year":2006,"lang":"en","type":"article","venue":"Blood","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":200,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Bayer HealthCare","keywords":"Genetic enhancement; Factor IX; Medicine; Immunology; Antibody; Coagulation; Serotype; Therapeutic effect; Neutralizing antibody; Virology; Internal medicine; Gene; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006580521,0.0001052238,0.0001110494,0.00003901839,0.00004058201,0.00001488685,0.00009069789,0.00007273804,0.00001088544],"category_scores_gemma":[0.000007822566,0.00009977331,0.00002692305,0.00005455603,0.00004614916,0.000002513792,0.0000881481,0.00004475086,0.000002864304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003086491,"about_ca_system_score_gemma":0.00001667782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001981957,"about_ca_topic_score_gemma":0.0005149575,"domain_scores_codex":[0.9993637,0.00002042883,0.0001102231,0.0002392037,0.00009292139,0.0001734989],"domain_scores_gemma":[0.9996758,0.00001029937,0.0000268055,0.0001745883,0.00005112846,0.00006134719],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002551725,0.00008076157,0.01038489,0.00002310561,0.00005284516,0.000001406837,0.00004910774,0.00001580405,0.985762,0.0000134451,0.000006391518,0.00335507],"study_design_scores_gemma":[0.001113033,0.00103189,0.03028652,0.0000108053,0.00001822566,0.000008098556,0.00001255637,0.00002137107,0.9666992,0.00005570422,0.0006151359,0.0001275058],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965805,0.003004817,0.00002839013,0.00006220328,0.00001149117,0.0001796476,0.00002981426,0.000006894282,0.00009622172],"genre_scores_gemma":[0.9990224,0.0001885975,0.0004203145,0.00009239509,0.000062863,0.000009416229,0.000008899051,0.00001850407,0.0001765915],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01990163,"threshold_uncertainty_score":0.4068637,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01128756220576979,"score_gpt":0.2560969159999344,"score_spread":0.2448093537941646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}