{"id":"W2153867928","doi":"10.1182/blood-2005-12-5115","title":"Multiyear therapeutic benefit of AAV serotypes 2, 6, and 8 delivering factor VIII to hemophilia A mice and dogs","year":2006,"lang":"en","type":"article","venue":"Blood","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":200,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Bayer HealthCare","keywords":"Genetic enhancement; Factor IX; Medicine; Immunology; Antibody; Coagulation; Serotype; Therapeutic effect; Neutralizing antibody; Virology; Internal medicine; Gene; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003644224,0.0003389634,0.0004458136,0.0004040514,0.0001548465,0.0004024618,0.0002541026,0.0004747665,0.0006156047],"category_scores_gemma":[0.0002541433,0.0001241701,0.0003021205,0.000120661,0.0002172331,0.0004800489,0.0002171565,0.0007337235,0.0001839532],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002359175,"about_ca_system_score_gemma":0.0001487392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002788252,"about_ca_topic_score_gemma":0.0004137426,"domain_scores_codex":[0.9997501,0.00003633258,0.00002415285,0.00006905109,0.00006213665,0.00005819783],"domain_scores_gemma":[0.9996268,0.00004528994,0.0001493929,0.00004012696,0.00003374848,0.0001046384],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008179131,0.0005381447,0.001241274,0.00006541811,0.00004313868,0.0001338276,0.00006623147,0.0004625239,0.9822361,0.0002564713,0.0003410719,0.01379798],"study_design_scores_gemma":[0.0003238316,0.04572731,0.0371292,0.00007721144,0.0004186361,0.004823391,0.0001732993,0.0065889,0.8865178,0.0003679924,0.01777972,0.00007277739],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926142,0.002798491,0.003345207,0.00008622582,0.00004377687,0.00003458837,0.0001801204,0.0001701718,0.0007272196],"genre_scores_gemma":[0.9942282,0.001246213,0.002159849,0.0000578397,0.00002896654,0.00007812081,0.0004273327,0.00003411765,0.00173932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006156047,"threshold_uncertainty_score":0.0020594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01128756220576979,"score_gpt":0.2560969159999344,"score_spread":0.2448093537941646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}